7-Dehydrocholesterol
Based on 8 publication(s) in Google Scholar
7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3.
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- Purity: 99.97%
- CAS No.: 434-16-2
- 화학식: C27H44O
- 분자량:384.64
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) 7-Dehydrocholesterol
More- Adv Sci (Weinh). 2025 Nov 7:e18323. [Abstract]
- Chem Eng J. 2025 Aug 1.
- Cell Chem Biol. 2024 May 16;31(5):920-931.e6. [Abstract]
- Anal Chim Acta. 2026 Jun 16;1418:345855.
- Virol Sin. 2024 Oct;39(5):802-811. [Abstract]
- Insect Biochem Mol Biol. 2026 Mar:188:104499. [Abstract]
- Biochem Biophys Res Commun. 2026 Jan 1:794:153070. [Abstract]
- Research Square Preprint. 2023 Jun 22.
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Biological Activity
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Human Endogenous Metabolite |
7-Dehydrocholesterol is a biosynthetic precursor of cholesterol and vitamin D3. 7-Dehydrocholesterol is present in relatively high concentration in skin where it is converted to pre-vitamin D3 upon UV irradiation and where it is also exposed to exogenous radical sources and oxygen[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 434-16-2
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Appearance Solid
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분자량 384.64
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화학식 C27H44O
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Color White to light yellow
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SMILES
CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (8)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Fe-S Protein FDX1 Triggers Tumor-Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC. [Abstract]2025 Nov 7:e18323. PMID: 41199656 -
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Cell Chem Biol
Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity. [Abstract]2024 May 16;31(5):920-931.e6. PMID: 38759618
7-Dehydrocholesterol purchased from MedChemExpress. Usage Cited in: Cell Chem Biol. 2024 May 16;31(5):920-931.e6. [Abstract]
Mouse naive CD8+ T cells were transiently treated with 1 or 2 ng/μL 7-Dehydrocholesterol (7a-HC) in A and 2 ng/μL 7a-HC for 20 min.
7-Dehydrocholesterol purchased from MedChemExpress. Usage Cited in: Cell Chem Biol. 2024 May 16;31(5):920-931.e6. [Abstract]
Effects of transient 7-Dehydrocholesterol (7a-HC) treatment on the phosphorylation levels of TCR and downstream molecules in mouse T cells. Mouse naive CD4+ T cells were transiently treated with 2 ng/μL 7a-HC for 20 min and then stimulated with 5 ng/μL α-CD3ε and 5 ng/μL α-CD28.
7-Dehydrocholesterol purchased from MedChemExpress. Usage Cited in: Cell Chem Biol. 2024 May 16;31(5):920-931.e6. [Abstract]
Naïve mouse CD8+ T cells were treated with 10 ng/μL cholesterol, 2 ng/μL 7-Dehydrocholesterol (7a-HC) for 20 min, or without any treatment. The plasma membrane was then labeled with octadecylrhodamine B (R18).
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Virol Sin
Antiviral activity of vitamin D derivatives against severe fever with thrombocytopenia syndrome virus in vitro and in vivo. [Abstract]2024 Oct;39(5):802-811. PMID: 39168248 -
Insect Biochem Mol Biol
2026 Mar:188:104499. PMID: 41548698 -
Biochem Biophys Res Commun
7-dehydrocholesterol promotes CCL2-secretion from porcine skeletal muscle satellite cells, enhancing the migration of preadipocytes. [Abstract]2026 Jan 1:794:153070. PMID: 41344212
7-Dehydrocholesterol purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2026 Jan 1:794:153070. [Abstract]
Cell viability of MuSCs with different concentrations of 7-Dehydrocholesterol (7-DHC).
7-Dehydrocholesterol purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2026 Jan 1:794:153070. [Abstract]
The protein level of CCL2 in MuSCs after pre-treatment of MuSCs with 7-Dehydrocholesterol (7-DHC) (in a co-culture system).
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용액&용해도
Ethanol : 12.5 mg/mL (32.50 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.83 mg/mL (2.16 mM); Clear solution
This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (8.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 0.83 mg/mL (2.16 mM); Clear solution
This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (8.3 mg/mL) to 900 μL Corn oil, and mix evenly.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Data Sheet (272 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 2.5998 mL | 12.9992 mL | 25.9983 mL | 64.9958 mL |
| 5 mM | 0.5200 mL | 2.5998 mL | 5.1997 mL | 12.9992 mL | |
| 10 mM | 0.2600 mL | 1.2999 mL | 2.5998 mL | 6.4996 mL | |
| 15 mM | 0.1733 mL | 0.8666 mL | 1.7332 mL | 4.3331 mL | |
| 20 mM | 0.1300 mL | 0.6500 mL | 1.2999 mL | 3.2498 mL | |
| 25 mM | 0.1040 mL | 0.5200 mL | 1.0399 mL | 2.5998 mL | |
| 30 mM | 0.0867 mL | 0.4333 mL | 0.8666 mL | 2.1665 mL |
7-Dehydrocholesterol Related Classifications
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