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Roxadustat

(Synonyms: FG-4592)
64 Cited Publications
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Based on 64 publication(s) in Google Scholar

Roxadustat is an orally active hypoxia-inducible factor prolyl-hydroxylase (PHD) inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin.

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  • Purity: 99.92%
  • CAS No.: 808118-40-3
  • 화학식: C19H16N2O5
  • 분자량:352.34
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Roxadustat Chemical Structure
    Roxadustat Chemical Structure
  • Experimental Validation Results for Roxadustat
  • Experimental Validation Results for Roxadustat
  • Experimental Validation Results for Roxadustat
CAS No.: 808118-40-3
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WBIF
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All HIF/HIF Prolyl-Hydroxylase Isoforms

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  • Roxadustat Chemical Structure
    Roxadustat Chemical Structure
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  • 1/16

    Roxadustat purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2019 Jan;23(1):349-356. [Abstract]

    Customer Validation
     FG-4592 increases level of HIF-1α and regulates apoptosis-related proteins in AHH-1. The effects of FG-4592 on HIF1-α are detected using Western Blot. Level of HIF-1α is measured at different time points after the treatment of FG-4592 (A). Cell lysate is obtained at 6 h after irradiation and used to evaluate the regulation of FG-4592 on apoptosis-related molecules. Apoptosis promoting molecules (c-caspase3 and cyt-c) are downregulated and molecules that inhibit apoptosis are up-regulated by FG-4

  • 1/16

    Roxadustat purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2019 Jan;23(1):349-356. [Abstract]

    Customer Validation
     FG-4592 mitigates radiation-induced DNA injuries. AHH-1 cells pretreated with or without FG-4592 are exposed to 6 Gy irradiation and γ-H2AX assay is used to determine DNA damages at 0, 0.5, 2 h after irradiation.

  • 1/16

    Roxadustat purchased from MedChemExpress. Usage Cited in: Science. 2016 Apr 1;352(6281):54-61. [Abstract]

    Customer Validation
     FG-4592 causes normoxic stabilization of HIF1α and rewires energy metabolism. Immunoblot showing HIF1α ± RC inhibition with antimycin or oligomycin, ± FG-4592 under normoxia (21% O2) or hypoxia (1% O2). RC inhibition prevents HIF1α stabilization during hypoxia. FG-4592 administration overcomes this paradox and stabilizes HIF1α even during normoxia. Immunoblot is representative of independent experiments done in duplicate in HT-29 cells.

  • Roxadustat