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LGK974

(Synonyms: WNT974)
47 Cited Publications
고객리뷰

Based on 47 publication(s) in Google Scholar

LGK974 (WNT974) is an orally bioavailable and specific Porcupine (PORCN) inhibitor with an IC50 of 0.1 nM.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

  • Purity: 99.93%
  • CAS No.: 1243244-14-5
  • 화학식: C23H20N6O
  • 분자량:396.44
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • LGK974 Chemical Structure
    LGK974 Chemical Structure
  • Experimental Validation Results for LGK974
  • Experimental Validation Results for LGK974
  • Experimental Validation Results for LGK974
  • Experimental Validation Results for LGK974
  • Experimental Validation Results for LGK974
  • Experimental Validation Results for LGK974
CAS No.: 1243244-14-5
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Histological Imaging/StainingIn Vivo Efficacy StudyWBIF
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  • Histological Imaging/Staining
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  • In Vivo Efficacy Study
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  • LGK974 Chemical Structure
    LGK974 Chemical Structure
    1/16
  • 1/16

    LGK974 purchased from MedChemExpress. Usage Cited in: Neuro Oncol. 2023 Jun 2;25(6):1073-1084. [Abstract]

    Customer Validation
     LGK974 (2.5 mg/kg; 4 days; i.g.). Immunohistochemical staining of CD31 in RCAS/tv-a glioma from mice treated with or without LGK974 was performed.

  • 1/16

    LGK974 purchased from MedChemExpress. Usage Cited in: Neuro Oncol. 2023 Jun 2;25(6):1073-1084. [Abstract]

    Customer Validation
     LGK974 (2.5 mg/kg; 4 days; i.g.). Co-immunofluorescence staining and quantification of β-catenin and CD31 in RCAS/tv-a glioma tumors from mice treated with or without LGK974 were performed.

  • 1/16

    LGK974 purchased from MedChemExpress. Usage Cited in: Neuro Oncol. 2023 Jun 2;25(6):1073-1084. [Abstract]

    Customer Validation
     LGK974 (2.5 mg/kg; 4 days; i.g.) was administered. The survival curve of CT-2A glioma-bearing mice treated with LGK974 and/or TMZ was analyzed.

  • 1/16

    LGK974 purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2021 Mar;53(3):407-421. [Abstract]

    Customer Validation
     C57BL/6 mice were injected i.p. with 0–60 mg/kg LGK974 2 h before being injected with 25 mg/kg LPS. Cytokine concentrations in the plasma were determined using a magnetic Luminex assay.

  • 1/16

    LGK974 purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2020 Sep 3;27(3):413-429.e4. [Abstract]

    Customer Validation
     IF images of uninjured, 48 hpi, and 72 hpi mouse airway epithelia wild-type mice treated with vehicle or LGK974 assessing BrdU incorporation. Relative to vehicle-treated mice, LGK974-treated mice exhibited an attenuated SAE with few BrdU+ ABSCs, thereby phenocopying the repair response of K5-CreER;Ctnnb1fl/fl mouse tracheas.

  • 1/16

    LGK974 purchased from MedChemExpress. Usage Cited in: Exp Cell Res. 2016 Jul 15;345(2):206-17. [Abstract]

    Customer Validation
     Inhibition of PORCN abolishes Runx2 induction stimulated by β-GP. VSMCs are pretreated with LGK974 (1nM) for 30 min, then incubated with β-GP (10mM) for 24h, and the cell lysates are immunoblotted with antibodies against Runx2 and β-actin, respectively.

  • LGK974