Thiazolyl Blue
(Synonyms: MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide)
192 Cited Publications
고객리뷰
Based on 192 publication(s) in Google Scholar
Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.84%
- CAS No.: 298-93-1
- 화학식: C18H16BrN5S
- 분자량:414.32
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보관:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Thiazolyl Blue
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- Mol Cancer. 2025 Dec 11;24(1):306. [Abstract]
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- Cell Mol Immunol. 2021 Mar;18(3):613-620. [Abstract]
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- Acta Biomater. 2024 Sep 5:S1742-7061(24)00501-4. [Abstract]
- Cell Death Dis. 2023 Oct 11;14(10):671. [Abstract]
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- Eur Rev Med Pharmacol Sci. 2021 Aug;25(16):5293-5303. [Abstract]
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Biological Activity
제품 설명
Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis[1].
In Vitro
Guide (The following is the experimental plan we recommend. This plan serves only as a reference guide. The specific operations should be adjusted according to your actual needs.)
1. Preparation of MTT solution
Dissolve MTT in anhydrous DMSO to obtain a 5 mg/mL solution.
2. Cell proliferation assay (96-well plate)
2.1 Cell inoculation: Prepare single cells and prepare a suspension with 10% FBS culture medium. Inoculate them into a 96-well plate, with 1000-10,000 cells per well, and each well volume is 100 μL.
2.2 Cell culture: At 37°C, with 5% CO2, incubate for 24-72 hours.
2.3 Add 10 μL of MTT to each well, incubate for 4 hours, discard the supernatant, and the cells need to be centrifuged first.
2.4 Add 100 μL of DMSO, shake for 10 minutes to completely dissolve the crystals.
2.5 Use an absorbance plate reader to monitor the increase in absorbance at OD = 562 nm.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 298-93-1
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Appearance Solid
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분자량 414.32
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화학식 C18H16BrN5S
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Color Light yellow to yellow
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SMILES
CC1=C(C)N=C(N2N=C(C3=CC=CC=C3)N=[N+]2C4=CC=CC=C4)S1.[Br-]
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Synonyms
MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)
Publications (192)
All
Journal Impact Factor
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Journal Impact Factor
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Most Recent
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ACS Appl Mater Interfaces
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Sci Total Environ
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NPJ Precis Oncol
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Sci Total Environ
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NPJ Sci Food
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J Med Chem
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J Med Chem
5α-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2. [Abstract]2021 Sep 9;64(17):12537-12547. PMID: 34351142 -
J Med Chem
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Main Bioactive Components and Their Biological Activities from Natural and Processed Rhizomes of Polygonum sibiricum. [Abstract]2022 Jul 17;11(7):1383. PMID: 35883874 -
NPJ Regen Med
Alkaline shear-thinning micro-nanocomposite hydrogels initiate endogenous TGFβ signaling for in situ bone regeneration. [Abstract]2023 Oct 13;8(1):56. PMID: 37833374 -
Int J Pharm X
Formulation of multicomponent inclusion complex of cyclodextrin-amino acid with Chrysin: Physicochemical characterization, cell viability and apoptosis assessment in human primary glioblastoma cell line. [Abstract]2023 Sep 12:6:100211. PMID: 37736236 -
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Ecotoxicol Environ Saf
Arsenic exposure provoked prostatic PANoptosis by inducing mitochondrial dysfunction in mice and WPMY-1 cells. [Abstract]2025 Apr 3:295:118139. PMID: 40185034 -
Ecotoxicol Environ Saf
N6-methyladenosine facilitates arsenic-induced neoplastic phenotypes of human bronchial epithelial cells by promoting miR-106b-5p maturation. [Abstract]2024 Sep 15:283:116803. PMID: 39094460 -
Ecotoxicol Environ Saf
Alleviating 3-MCPD-induced male reproductive toxicity: Mechanistic insights and resveratrol intervention. [Abstract]2024 Feb:271:115978. PMID: 38262097 -
Eur J Med Chem
Discovery of a selenium-containing compound as a promising ferroptosis inducer attenuates prostate cancer progression. [Abstract]2025 Dec 5:299:118067. PMID: 40834498 -
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Eur J Med Chem
Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer. [Abstract]2020 Nov 15;206:112677. PMID: 32823005 -
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Eur J Med Chem
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용액&용해도
In Vitro:
DMSO : 25 mg/mL (60.34 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 0.88 mg/mL (2.12 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
View the Complete Stock Solution Preparation Table
Preparing Stock Solutions
View the Complete Stock Solution Preparation Table
Concentration
Solvent
Mass
1 mg
5 mg
10 mg
Concentration
Solvent
Mass
1 mM
2.4136 mL
12.0680 mL
24.1359 mL
5 mM
0.4827 mL
2.4136 mL
4.8272 mL
10 mM
0.2414 mL
1.2068 mL
2.4136 mL
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
몰농도 계산기
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
=
×
×
농도 희석 계산기
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
Select Batch:
Purity:
99.98%
Assay:
99.98%
ee.:
99.98%
-
Data Sheet (278 KB)
-
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Berridge MV, et al. Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnol Annu Rev. 2005;11:127-52. [Content Brief]
[2]. Berridge MV, et al. Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnol Annu Rev. 2005;11:127-52. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.4136 mL | 12.0680 mL | 24.1359 mL | 60.3398 mL |
| DMSO | 5 mM | 0.4827 mL | 2.4136 mL | 4.8272 mL | 12.0680 mL |
| 10 mM | 0.2414 mL | 1.2068 mL | 2.4136 mL | 6.0340 mL | |
| 15 mM | 0.1609 mL | 0.8045 mL | 1.6091 mL | 4.0227 mL | |
| 20 mM | 0.1207 mL | 0.6034 mL | 1.2068 mL | 3.0170 mL | |
| 25 mM | 0.0965 mL | 0.4827 mL | 0.9654 mL | 2.4136 mL | |
| 30 mM | 0.0805 mL | 0.4023 mL | 0.8045 mL | 2.0113 mL | |
| 40 mM | 0.0603 mL | 0.3017 mL | 0.6034 mL | 1.5085 mL | |
| 50 mM | 0.0483 mL | 0.2414 mL | 0.4827 mL | 1.2068 mL | |
| 60 mM | 0.0402 mL | 0.2011 mL | 0.4023 mL | 1.0057 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Thiazolyl Blue Related Classifications
HY-15924 Related Classifications
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