Orexin A (human, rat, mouse)
Based on 12 publication(s) in Google Scholar
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.
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- Purity: 99.58%
- CAS No.: 205640-90-0
- 화학식: C152H243N47O44S4
- 분자량:3561.10
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Orexin A (human, rat, mouse)
More- Research (Wash D C). 2024 May 31:7:0384. [Abstract]
- J Neuroinflammation. 2026 May 5;23(1):216. [Abstract]
- J Neuroinflammation. 2024 May 17;21(1):131. [Abstract]
- CNS Neurosci Ther. 2025 Sep;31(9):e70606. [Abstract]
- CNS Neurosci Ther. 2024 Nov;30(11):e70096. [Abstract]
- Food Funct. 2024 Aug 27;15(17):8661-8673. [Abstract]
- Exp Neurol. 2025 Nov:393:115378. [Abstract]
- J Inflamm Res. 2021 May 18:14:2007-2017. [Abstract]
- Brain Res Bull. 2021 Apr;169:81-93. [Abstract]
- Neuropeptides. 2025 Jan 4:110:102501. [Abstract]
- Med Sci Monit. 2019 Apr 19:25:2886-2895. [Abstract]
- bioRxiv. 2026 Jan 23.
Customer Validation & Images
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Histological Imaging/Staining
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RT-PCR
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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WB
All Orexin Receptor (OX Receptor) Isoforms
More
Biological Activity
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OX1 Receptor |
OX2 Receptor |
Orexin A (human, rat, mouse) has high affinity for OX1R and OX2R, with 38 nM IC50 and 34 nM EC50 values in the the [Ca2﹢]i transient assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Orexin A (human, rat, mouse) (3, 10 and 30 mg/kg; i.v.) was given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4±35.2 s in vehicle-treated mice to 500.3±31.2 s at 10 mg/kg and 594.5±5.5 s at 30 mg/kg[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female mice (mouse carrageenan-induced thermal hyperalgesia test)[2]
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Dosage:3, 10 and 30 mg/kg
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Administration:i.v.; 5 min pre-test
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Result:Significantly increased the latency to response at 10 and 30 mg/kg.
Chemical Information
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CAS No. 205640-90-0
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Appearance Solid
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분자량 3561.10
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화학식 C152H243N47O44S4
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Color White to off-white
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Synonyms
Hypocretin-1 (human, rat, mouse)
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Sequence
{Glp}-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)
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Sequence Shortening
{Glp}-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (12)
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Journal Impact Factor
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Most Recent
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Research (Wash D C)
Repetitive Transcranial Magnetic Stimulation (rTMS) Improves Cognitive Impairment and Intestinal Microecological Dysfunction Induced by High-Fat Diet in Rats. [Abstract]2024 May 31:7:0384. PMID: 38826566
Orexin A (human, rat, mouse) purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2024 May 31:7:0384. [Abstract]
Schematic illustration of the effect of different concentrations of Orexin A (human, rat, mouse) on inflammatory factors expression in BV2. In addition, the mRNA expression of TNF-α, IL-6, IL-1β, and inducible nitric oxide synthase (iNOS) in different groups.
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J Neuroinflammation
SARS-CoV-2 infection is associated with hypothalamic orexin suppression and persistent cortical NeuN attenuation. [Abstract]2026 May 5;23(1):216. PMID: 42087199 -
J Neuroinflammation
2024 May 17;21(1):131. PMID: 38760784
Orexin A (human, rat, mouse) purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 May 17;21(1):131. [Abstract]
Treatment with 250 µg/kg Orexin A (human, rat, mouse) increases 7-day survival. Orexin A (human, rat, mouse) was administered at 250 µg/kg, 30 min after CLP induction, in a volume of 2.5 µl per nostril (5.0 µl per mouse).
Orexin A (human, rat, mouse) purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 May 17;21(1):131. [Abstract]
Treatment with 250 µg/kg Orexin A (human, rat, mouse) ameliorates cognitive and affective deficits in CLP-induced sepsis. Time in the central zone and distance of activity in the open field. Orexin A (human, rat, mouse) was administered at 250 µg/kg, 30 min after CLP induction, in a volume of 2.5 µl per nostril (5.0 µl per mouse).
Orexin A (human, rat, mouse) purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 May 17;21(1):131. [Abstract]
Orexin A (human, rat, mouse) reduces inflammation by decreasing Rras expression and impeding activation of the RAS/MAPK pathway.
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CNS Neurosci Ther
Neuroprotective Effects of Transcranial Pulsed Current Stimulation: Modulation of Microglial Polarization in Traumatic Brain Injury. [Abstract]2025 Sep;31(9):e70606. PMID: 40916543 -
CNS Neurosci Ther
Orexin-A Attenuates the Inflammatory Response in Sepsis-Associated Encephalopathy by Modulating Oxidative Stress and Inhibiting the ERK/NF-κB Signaling Pathway in Microglia and Astrocytes. [Abstract]2024 Nov;30(11):e70096. PMID: 39508266
Orexin A (human, rat, mouse) purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2024 Nov;30(11):e70096. [Abstract]
Orexin A (human, rat, mouse) treatment attenuates hippocampal neuronal damage after CLP. Intranasal administration of 250 μg/kg of Orexin A (human, rat, mouse) drug, 2.5 μL per nostril, and 5.0 μL per mouse was used in this experiment. TUNEL staining showing neuronal apoptosis and quantification of TUNEL (green) with DAPI (blue) in the CA1 area of the hippocampus 7 days after CLP.
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Food Funct
A high-fat diet induced depression-like phenotype via hypocretin-HCRTR1 mediated inflammation activation. [Abstract]2024 Aug 27;15(17):8661-8673. PMID: 39056112 -
Exp Neurol
Orexin A alleviates chronic cerebral hypoperfusion-induced neuroinflammation and cognitive dysfunction by inhibiting the NEK7/NLRP3 pathway. [Abstract]2025 Nov:393:115378. PMID: 40691984 -
J Inflamm Res
Orexin-A Attenuates Inflammatory Responses in Lipopolysaccharide-Induced Neural Stem Cells by Regulating NF-KB and Phosphorylation of MAPK/P38/Erk Pathways. [Abstract]2021 May 18:14:2007-2017. PMID: 34040413 -
Brain Res Bull
Trigeminal nerve electrical stimulation: An effective arousal treatment for loss of consciousness. [Abstract]2021 Apr;169:81-93. PMID: 33453332 -
Neuropeptides
Transcranial pulsed current stimulation alleviates neuronal pyroptosis and neurological dysfunction following traumatic brain injury via the orexin-A/NLRP3 pathway. [Abstract]2025 Jan 4:110:102501. PMID: 39764896 -
Med Sci Monit
2019 Apr 19:25:2886-2895. PMID: 31002658 -
용액&용해도
DMSO : 100 mg/mL (28.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (293 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. [Content Brief]
[2]. Bingham S, et al. Orexin-A, an hypothalamic peptide with analgesic properties. Pain. 2001 May;92(1-2):81-90. [Content Brief]
[3]. Kaminski T, et al. Expression of orexin receptors in the pituitary. Vitam Horm. 2012;89:61-73. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.2808 mL | 1.4041 mL | 2.8081 mL | 7.0203 mL |
| 5 mM | 0.0562 mL | 0.2808 mL | 0.5616 mL | 1.4041 mL | |
| 10 mM | 0.0281 mL | 0.1404 mL | 0.2808 mL | 0.7020 mL | |
| 15 mM | 0.0187 mL | 0.0936 mL | 0.1872 mL | 0.4680 mL | |
| 20 mM | 0.0140 mL | 0.0702 mL | 0.1404 mL | 0.3510 mL | |
| 25 mM | 0.0112 mL | 0.0562 mL | 0.1123 mL | 0.2808 mL |
Orexin A (human, rat, mouse) Related Classifications
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