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STF-083010

53 Cited Publications
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Based on 53 publication(s) in Google Scholar

STF-083010 is a specific IRE1α inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress.

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  • Purity: 98.0%
  • CAS No.: 307543-71-1
  • 화학식: C15H11NO3S2
  • 분자량:317.38
  • 보관:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • STF-083010 Chemical Structure
    STF-083010 Chemical Structure
  • Experimental Validation Results for STF-083010
  • Experimental Validation Results for STF-083010
  • Experimental Validation Results for STF-083010
  • Experimental Validation Results for STF-083010
CAS No.: 307543-71-1
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  • STF-083010 Chemical Structure
    STF-083010 Chemical Structure
    1/16
  • 1/16

    STF-083010 purchased from MedChemExpress. Usage Cited in: Exp Anim. 2018 Jul 30;67(3):373-382. [Abstract]

    Customer Validation
     Effect of STF-083010 administration on endoplasmic reticulum (ER) stress of acute renal failure (ARF) kidneys.

  • 1/16

    STF-083010 purchased from MedChemExpress. Usage Cited in: Viruses. 2017 Aug 23;9(9). pii: E235.  [Abstract]

    Customer Validation
     IRE1 kinase activity inhibitor represses JNK activation induced by viral infection in HEC-1-A cells. HEC-1-A cells were pretreated or mock-pretreated with APY29, only or both APY29, and STF-083010 for 30 min and then infected or mock-infected with HSV-1.

  • 1/16

    STF-083010 purchased from MedChemExpress. Usage Cited in: Viruses. 2017 Aug 23;9(9). pii: E235.  [Abstract]

    Customer Validation
     HEC-1-A cells are pretreated or mockpretreated with Tg for 30 min then mock-infected or infected with HSV-1 or treated with STF-083010. Total cellular RNA is extracted after 12 h p.i. and the mRNA levels are determined by real-time PCR.

  • 1/16

    STF-083010 purchased from MedChemExpress. Usage Cited in: Viruses. 2017 Aug 23;9(9). pii: E235.  [Abstract]

    Customer Validation
     Inhibition of IRE1 kinase activity has an inhibitory effect on HSV-1 replication in HEC-1-A cells. Cells are presence or absence of APY29 or STF-083010 or both of two drugs and then infected with HSV-1 (HF). Total cellular cells lysates are prepared at 24 h p.i. and subject to Western blot analysis against.

  • STF-083010