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Cat. No.: HY-184961

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Anticancer agent 353

Anticancer agent 353 is a heterobifunctional antitumor agent with weak ERα inhibitory activity and anticancer activity. Anticancer agent 353 exhibits growth inhibitory activity against MCF7 cells. Anticancer agent 353 can be used in cancer research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3099598-10-1
화학식: C₅₂H₅₈N₈OS
분자량:843.13

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 353 Chemical Structure

CAS No.: 3099598-10-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

ERα

All Estrogen Receptor/ERR Isoforms :

In Vitro

Anticancer agent 353 (III-146) exhibits growth inhibitory activity against MCF7 cells, with a GI₅₀ of < 0.05 μM^[1].
Anticancer agent 353 exhibits activity in both Doxorubicin (HY-15142A)-induced ERα-overexpressing and non-induced T-Rex 293 cells, with consistent antiproliferative activity between the two groups (GI₅₀ = 0.5-2.5 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3099598-10-1
분자량 843.13
화학식 C₅₂H₅₈N₈OS
SMILES

OC1=CC=C([C@@H](C2=CC=C(N3CC(C3)CN4CCN(CC4)CC5CN(C6=CC=C(C7=N[C@H](C)C8=NN=C(C)N8C9=C7C(C)=C(C)S9)C=C6)C5)C=C2)[C@@H](C%10=CC=CC=C%10)CC%11)C%11=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Eastman KJ, et al. Heterobifunctional compounds and their use in treating disease. WO2025189056 A1. WIPO. 2025.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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