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Cat. No.: HY-165484

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AVP-13358

Name: AVP-13358
Brand: MedChemExpress
SKU: HY-165484
Price: 388.00 USD
Availability: InStock
Rating: 5 (1 reviews)

AVP-13358 is an orally active IgE inhibitor that effectively suppresses immunoglobulin E (IgE)-mediated immune responses, with IC₅₀ values of 8 and 3 nM for IgE inhibition in vivo and in vitro in BALB/c mice, respectively. AVP-13358 acts directly on T cells, inhibiting the production and release of IL-4, IL-5, and IL-13. It also targets other markers critical for the development of allergic responses, including the B cell IgE receptor (CD23) in human monocytes and the CD23 and IL-4 receptors in mouse B cells. AVP-13358 can be used in research related to anti-allergic responses.

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CAS No.: 459805-03-9
화학식: C₃₀H₂₉N₅O₂
분자량:491.58

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

AVP-13358 Chemical Structure

CAS No.: 459805-03-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

IC₅₀ & Target

IL-5

IL-13

IL-4

All Interleukin Related Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
B-cell	IC₅₀	8 nM Compound: 1i, AVP-13358	Inhibition of IgE production in B lymphocytes from BALB/c mouse Inhibition of IgE production in B lymphocytes from BALB/c mouse	[PMID: 15588078]
Lymphocyte	IC₅₀	20 nM Compound: 1i, AVP-13358	Suppression of CD23 expression in IL4 and anti-CD3 antibody sensitized CD14-positive human peripheral blood lymphocytes Suppression of CD23 expression in IL4 and anti-CD3 antibody sensitized CD14-positive human peripheral blood lymphocytes	[PMID: 15588078]
Splenocyte	IC₅₀	100 nM Compound: 1i, AVP-13358	Suppression of IL4 receptor alpha expression in IL4 and anti-CD3 antibody sensitized mouse splenocytes Suppression of IL4 receptor alpha expression in IL4 and anti-CD3 antibody sensitized mouse splenocytes	[PMID: 15588078]
Splenocyte	IC₅₀	40 nM Compound: 1i, AVP-13358	Suppression of CD23 expression in IL4 and anti-CD3 antibody sensitized mouse splenocytes Suppression of CD23 expression in IL4 and anti-CD3 antibody sensitized mouse splenocytes	[PMID: 15588078]
T-cell	IC₅₀	30 nM Compound: 1i, AVP-13358	Inhibition of IL13 production in conA and anti-CD3 antibody sensitized BALB/c mouse spleen T lymphocytes Inhibition of IL13 production in conA and anti-CD3 antibody sensitized BALB/c mouse spleen T lymphocytes	[PMID: 15588078]
T-cell	IC₅₀	30 nM Compound: 1i, AVP-13358	Inhibition of IL4 production in conA and anti-CD3 antibody sensitized BALB/c mouse spleen T lymphocytes Inhibition of IL4 production in conA and anti-CD3 antibody sensitized BALB/c mouse spleen T lymphocytes	[PMID: 15588078]
T-cell	IC₅₀	30 nM Compound: 1i, AVP-13358	Inhibition of IL5 production in conA and anti-CD3 antibody sensitized BALB/c mouse spleen T lymphocytes Inhibition of IL5 production in conA and anti-CD3 antibody sensitized BALB/c mouse spleen T lymphocytes	[PMID: 15588078]
Vero	IC₅₀	>2000 nM Compound: 1d	Antiviral activity against SV40-infected Vero cells Antiviral activity against SV40-infected Vero cells	[PMID: 17973358]
Vero	IC₅₀	>2000 nM Compound: 1d	Antiviral activity against VSV-infected Vero cells Antiviral activity against VSV-infected Vero cells	[PMID: 17973358]

Chemical Information

CAS No. 459805-03-9
분자량 491.58
화학식 C₃₀H₂₉N₅O₂
SMILES

O=C(C1=CC=C2N=C(C3=CC=C(NC(C45CC6CC(C5)CC(C4)C6)=O)C=C3)NC2=C1)NC7=NC=CC=C7
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Richards ML, et al. Novel 2-(substituted phenyl)benzimidazole derivatives with potent activity against IgE, cytokines, and CD23 for the treatment of allergy and asthma. J Med Chem. 2004 Dec 16;47(26):6451-4. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
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- IC₅₀ & Target
Chemical Information
순도&문서
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AVP-13358

All Interleukin Related Isoforms

Biological Activity

제품 설명

IC50 & Target

Cellular Effect

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AVP-13358 Related Classifications

HY-165484 Related Classifications

Bioz

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