Becatecarin
Becatecarin is a rebeccamycin analog with antitumor effects. Becatecarin intercalates into DNA and inhibites the catalytic activity of topoisomerases I/II.
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- CAS No.: 119673-08-4
- 화학식: C33H34Cl2N4O7
- 분자량:669.55
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Topoisomerase Isoforms
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Biological Activity
제품 설명
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 119673-08-4
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분자량 669.55
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화학식 C33H34Cl2N4O7
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SMILES
ClC1=CC=CC2=C1NC3=C2C4=C(C(N(CCN(CC)CC)C4=O)=O)C5=C3N([C@@H]6O[C@H](CO)[C@@H](OC)[C@H](O)[C@H]6O)C7=C(Cl)C=CC=C75
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Synonyms
NSC 655649; BMS 181176; BMY 27557
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Long BH, Rose WC, Vyas DM, Matson JA, Forenza S. Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Curr Med Chem Anticancer Agents. 2002;2(2):255-266. [Content Brief]
[2]. Robey RW, Obrzut T, Shukla S, et al. Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells. Cancer Chemother Pharmacol. 2009;64(3):575-583. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Becatecarin Related Classifications
HY-13565 Related Classifications
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