BNTX
BNTX (7-Benzylidenenaltrexone) is a highly selective δ1 opioid receptor antagonist. BNTX selectively antagonizes the antinociceptive activity mediated by spinal δ1 opioid receptors, and does not alter the antinociceptive effects mediated by δ2, μ or κ opioid receptors at selective doses.
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- CAS No.: 129468-28-6
- 화학식: C27H27NO4
- 분자량:429.51
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
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δ Opioid Receptor/DOR |
BNTX is highly selective for δ1 opioid receptors in guinea pig brain membranes, with 100-fold greater affinity for δ1 versus δ2 sites[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ND4 Swiss-Webster (male, 20-25 g)[1]
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Dosage:1.3 μmol/kg (s.c. pretreatment); 1 pmole/mouse (i.t. pretreatment)
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Administration:s.c.; single dose, 30 minutes prior to agonist assay; i.t.; single dose, 10 minutes prior to agonist assay
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Result:Increased the antinociceptive ED50 of δ1 agonist DPDPE (i.t.) from 6.3 to 36.1 nmol/mouse at 1.3 μmol/kg s.c. dose.
Did not significantly alter the antinociceptive ED50 of δ2 agonist DELT II (i.t.), μ agonists DAMGO and morphine (i.t.), or κ agonist U-50,488H (i.t.), at 1.3 μmol/kg s.c. dose.
Increased the antinociceptive ED50 of DPDPE (i.t.) from 6.3 to 25.5 nmol/mouse at 1 pmole/mouse i.t. dose.
Did not significantly alter the antinociceptive ED50 of DELT II (i.t.), μ agonist DAMGO (i.t.), or κ agonist U-50,488H (i.t.), at 1 pmole/mouse i.t. dose.
Chemical Information
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CAS No. 129468-28-6
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분자량 429.51
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화학식 C27H27NO4
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SMILES
O[C@]12[C@@]34C5=C(C[C@@]2([H])N(CC4)CC6CC6)C=CC(O)=C5O[C@@]3([H])C(/C(C1)=C\C7=CC=CC=C7)=O
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Synonyms
7-Benzylidenenaltrexone
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BNTX Related Classifications
HY-169867 Related Classifications
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