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Cat. No.: HY-150941

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BRD4 ligand 2

BRD4 ligand 2 is a BRD4 BD1 inhibitor with an IC₅₀ of 46.4 nM. BRD4 ligand 2 inhibits the proliferation of lymphoma cells. BRD4 ligand 2 also serves as a target protein ligand for PROTACs, and is used in the synthesis of PROTAC BRD4 Degrader-1 (HY-133131). BRD4 ligand 2 is applicable to research related to lymphoma.

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CAS No.: 2133902-07-3
화학식: C₂₀H₁₉N₃O₂
분자량:333.38

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

BRD4 ligand 2 Chemical Structure

CAS No.: 2133902-07-3

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

BRD4 BD1

46.4 nM (IC₅₀)

All Epigenetic Reader Domain Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CT26	IC₅₀	35.98 μM Compound: 13	Antiproliferative activity against human CT26 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human CT26 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 33862375]
HCT-116	IC₅₀	3.341 μM Compound: 14	Antiproliferation activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferation activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33214826]
HepG2	IC₅₀	18.77 μM Compound: 13	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 33862375]
THP-1	IC₅₀	3.26 μM Compound: 6	Antiproliferative activity against human THP1 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo assay Antiproliferative activity against human THP1 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo assay	[PMID: 31813613]
U-266	IC₅₀	35.35 μM Compound: 13	Antiproliferative activity against human U-266 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human U-266 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 33862375]

In Vitro

BRD4 ligand 2 (Compound 6) potently inhibits BRD4 BD1 in the AlphaScreen biochemical assay, with an IC₅₀ value of 46.4 nM^[1].
BRD4 ligand 2 (72 h) inhibits the proliferation of human monocytic lymphoma THP-1 cells, with an IC₅₀ of 3.26 μM after 72 h of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

Chemical Information

CAS No. 2133902-07-3
분자량 333.38
화학식 C₂₀H₁₉N₃O₂
SMILES

CC1=NOC(C)=C1C2=CC=C3C(C(NC(N3C)=O)C4=CC=CC=C4)=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Zhang F, et al.. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorganic & medicinal chemistry. 2020 Jan 01;28(1):115228. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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