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Cat. No.: HY-184544

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CDK8 ligand 2

CDK8 ligand 2 is a steroidal CDK8 and CDK19 inhibitor with IC₅₀ values of 16 nM and 8 nM, respectively. CDK8 ligand 2 shows no activity against NEK1 (IC₅₀ >10,000 nM). As a target protein ligand, CDK8 ligand 2 is used for the synthesis of the CDK8 PROTAC degrader (HY-111518).

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CAS No.: 2374703-22-5
화학식: C₃₀H₄₂N₂
분자량:430.67

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDK8 ligand 2 Chemical Structure

CAS No.: 2374703-22-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

CDK8

16 nM (IC₅₀)

CDK19

8 nM (IC₅₀)

All CDK Isoforms :

In Vitro

CDK8 ligand 2 (compound 19) (5 µM) inhibits CDK8 activity in HepG2 cells and induces significant dephosphorylation of the CDK8 substrate S727-STAT1 at a concentration of 5 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2374703-22-5
분자량 430.67
화학식 C₃₀H₄₂N₂
SMILES

CN(C)[C@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H](C5=CC6=C(C=C5)C=CN=C6)CC[C@@]4([H])[C@]3([H])CC[C@@]2([H])C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Hatcher JM, et al. Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8. ACS medicinal chemistry letters. 2018 Jun 14;9(6):540-545. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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CDK8 ligand 2

All CDK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CDK8 ligand 2 Related Classifications

HY-184544 Related Classifications