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Cat. No.: HY-12144

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CP-99994

CP-99994 is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a K_i of 0.25 nM. CP-99994 prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity.

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CAS No.: 136982-36-0
화학식: C₁₉H₂₄N₂O
분자량:296.41

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

CP-99994 Chemical Structure

CAS No.: 136982-36-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

NK1R

0.25 nM (Ki)

All Neurokinin Receptor Isoforms :

All p38 MAPK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.5 nM Compound: 1	Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells	10.1016/0960-894X(95)00220-N
CHO	IC₅₀	0.5 nM Compound: 3	Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells	[PMID: 8627597]
CHO	IC₅₀	0.5 nM Compound: CP-99994	Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P. Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.	[PMID: 7535362]
CHO	IC₅₀	0.5 nM Compound: CP-99994	Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells	[PMID: 8709125]
CHO	IC₅₀	0.6 nM Compound: CP-99994	Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells	10.1016/0960-894X(95)00009-I
IM-9	IC₅₀	0.2 nM Compound: CP-99994	Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells	[PMID: 7543579]
IM-9	IC₅₀	0.49 nM Compound: 1, (CP-99994)	Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells	[PMID: 9871670]
IM-9	IC₅₀	0.63 nM Compound: CP-99994	Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cells Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cells	[PMID: 17967540]

Chemical Information

CAS No. 136982-36-0
분자량 296.41
화학식 C₁₉H₂₄N₂O
SMILES

COC(C=CC=C1)=C1CN[C@@H]2[C@H](C3=CC=CC=C3)NCCC2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. McLean S, et al. Pharmacology of CP-99,994; a nonpeptide antagonist of the tachykinin neurokinin-1 receptor. J Pharmacol Exp Ther. 1993 Oct;267(1):472-9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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CP-99994

High-Throughput Bioactive Compound Library

All Neurokinin Receptor Isoforms

All p38 MAPK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CP-99994 Related Classifications

HY-12144 Related Classifications