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Cat. No.: HY-P11856

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cPP12-2-Lys

cPP12-2-Lys is a cyclic cell-penetrating peptide that serves as a negative control, i.e., it lacks any NatD bisubstrate moiety. cPP12-2-Lys is not a NatD inhibitor (IC₅₀ = 9500 nM), but it possesses excellent cell-penetrating ability and can mediate the entry of conjugated bisubstrate inhibitors into non-small cell lung cancer (NSCLC) cells. cPP12-2-Lys can be used in NSCLC research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₆₄H₉₅N₂₃O₁₀S
분자량:1378.65

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

맞춤형 펩타이드 합성

cPP12-2-Lys Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Histone Acetyltransferase Isoforms :

In Vitro

cPP12-2-Lys (0.15 nM-30 μM; 30 min) alone shows very weak inhibitory activity against purified NatD enzyme with an IC₅₀ of 9500 nM^[1].
cPP12-2-Lys (5 μM; 2 h) is taken up by A549 non-small cell lung cancer cells, but at lower levels than its bisubstrate inhibitor-conjugated counterpart^[1].
cPP12-2-Lys (up to 10 μM; 48 h) does not reduce viability of A549 and H1299 non-small cell lung cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 1378.65
화학식 C₆₄H₉₅N₂₃O₁₀S
Sequence

Cyclo(Phe-d{Phe}-{Bta}-Arg-d{Arg}-Arg-d{Arg}-Gln)-Lys
Sequence Shortening

Cyclo(F-d{Phe}-{Bta}-R-d{Arg}-R-d{Arg}-Q)-K
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Ho YH, et al. A Cell-Potent Bisubstrate Inhibitor to Probe NatD Acetyltransferase Activity. ACS chemical biology. 2025 Oct 17;20(10):2512-2520. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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cPP12-2-Lys

All Histone Acetyltransferase Isoforms