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Cat. No.: HY-P10051

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Cyclorasin 9A5

Cyclorasin 9A5 is an 11-residue cell-permeable cyclic peptide that orthosterically inhibits the Ras-Raf protein interaction with an IC₅₀ of 120 nM.

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CAS No.: 1782098-79-6
화학식: C₇₅H₁₀₈FN₂₅O₁₃
분자량:1586.82

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cyclorasin 9A5 Chemical Structure

CAS No.: 1782098-79-6

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Bioz

Biological Activity

제품 설명

Cyclorasin 9A5 is an 11-residue cell-permeable cyclic peptide that orthosterically inhibits the Ras-Raf protein interaction with an IC₅₀ of 120 nM^[1].

IC₅₀ & Target

IC50: 120 nM (Ras-Raf protein interaction)^[1].

All Ras Isoforms :

All Raf Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H1299	EC₅₀	3 μM Compound: Cyclorasin 9A5	Induction of apoptosis in human NCI-H1299 cells by MTT assay Induction of apoptosis in human NCI-H1299 cells by MTT assay	[PMID: 34415745]

Chemical Information

CAS No. 1782098-79-6
분자량 1586.82
화학식 C₇₅H₁₀₈FN₂₅O₁₃
Sequence

Cyclo({d-Ala}-Arg-Arg-Arg-{d-Nal}-Arg-{4F-Phe}-{d-Nle}-Gln-Trp-Thr)
Sequence Shortening

Cyclo({d-Ala}-RRR-{d-Nal}-R-{4F-Phe}-{d-Nle}-QWT)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Koh Takeuchi, et al. Conformational Plasticity of Cyclic Ras-Inhibitor Peptides Defines Cell Permeabilization Activity. Angew Chem Int Ed Engl. 2021 Mar 15;60(12):6567-6572. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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수량:
MCE Japan Authorized Agent:

상품명:
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Cyclorasin 9A5

All Ras Isoforms

All Raf Isoforms