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Cat. No.: HY-176261

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DDD2

DDD2 is a selective and potent VHL-mediated PROTAC NUDT5 degrader. DDD2 induces robust NUDT5 degradation. DDD2 can be used in cancer research, such as lymphocytic leukemia and osteosarcoma.
(Pink: NUDT5 ligand (HY-176262); Blue: VHL ligand (HY-120217); Black: linker (HY-W001958)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₅₂H₆₆N₁₂O₉S
분자량:1035.22

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (287 KB)

DDD2 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

DDD2 is a selective and potent VHL-mediated PROTAC NUDT5 degrader. DDD2 induces robust NUDT5 degradation. DDD2 can be used in cancer research, such as lymphocytic leukemia and osteosarcoma^[1]. (Pink: NUDT5 ligand (HY-176262); Blue: VHL ligand (HY-120217); Black: linker (HY-W001958)).

IC₅₀ & Target^[1]

VHL

All PROTACs Isoforms :

In Vitro

DDD2 (2 µM, 24 h) induces robust NUDT5 degradation in U-2 OS cells^[1].

DDD2 (0.01-10 µM, 4-96 h) induces concentration- and time-dependent degradation of endogenous NUDT5 in CCRF-CEM cells^[1].

DDD2 (1 µM, 24 h) degrades NUDT5 depending on VHL not CRBN in U-2 OS cells^[1].

DDD2 has good solubility and stability with Kinetic Solubility Mean of 6.25 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

U-2 OS cells
Concentration:

2 µM
Incubation Time:

24 h, pretreating with Doxorubicin (HY-15142A) (1 µg/mL) to induce GFP1-10
Result:

Induced robust NUDT5 degradation.

Western Blot Analysis^[1]

Cell Line:

CCRF-CEM cells
Concentration:

0.01, 0.03, 0.1, 0.3, 1, 3, and 10 µM
Incubation Time:

4, 24, and 96 h
Result:

Showed concentration- and time-dependent degradation of endogenous NUDT5 and achieved Dmax at 24 h.

Chemical Information

분자량 1035.22
화학식 C₅₂H₆₆N₁₂O₉S
SMILES

O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(CCCCCCC(N2CCN(CC2)C3=NC4=C(C(N(C(N4C)=O)C)=O)N3CC5=NN=C(O5)C6=CC(OC)=C(C=C6)C)=O)=O)=O)NCC(C=C7)=CC=C7C(SC=N8)=C8C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (287 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Seher Alam, et al. A cell-based degrader assessment platform facilitates discovery of functional NUDT5 PROTACs. bioRxiv. June 19, 2025.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

DDD2

All PROTACs Isoforms