Dinaline
Dinaline (GOE 1734; PD 104 208; NSC 328786) is a potent and orally activity anticancer agent. Dinaline shows cytotoxicity and antitumor activity. Dinaline has the potential for the research of colorectal cancer.
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- CAS No.: 58338-59-3
- 화학식: C13H13N3O
- 분자량:227.26
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
12.6 μM
Compound: Dinaline
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Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
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[PMID: 20966043] |
| HepG2 | EC50 |
28.2 μM
Compound: Dinaline
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Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
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[PMID: 20966043] |
Dinaline (0.47-15 µg/mL; 48, 27 h) shows cytotoxicity for SW707, SW948 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SW707, SW948 cells
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Concentration:0.47, 0.95, 1.9, 3.8, 7.5, 15 µg/mL
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Incubation Time:48, 72 h
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Result:Inhibited cell growth with IC50s of 2.2, 1.0 µg/mL at 48 h and 1.2, 0.8 µg/mL at 72 h for SW707, SW948 cells, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:140-160 g, male Sprague-Dawley rats[1]
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Dosage:5.9, 7.7, 10 mg/kg
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Administration:P.o.; 5 days per week for 10 weeks
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Result:Showed significant tumor growth inhibition in a dose-dependent manner with the ratio of median tumor volume of (T/C%) values of 0.4, 16 and 10.6 at 10, 7.7 and 5.9 mg/kg respectively.
Chemical Information
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CAS No. 58338-59-3
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분자량 227.26
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화학식 C13H13N3O
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SMILES
O=C(C1=CC=C(C=C1)N)NC2=C(N)C=CC=C2
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Synonyms
GOE 1734; PD 104 208; NSC 328786
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dinaline Related Classifications
HY-W326094 Related Classifications
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