Efruxifermin
Based on 2 publication(s) in Google Scholar
Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 98.58%
- CAS No.: 2375240-92-7
- 분자량:91.863 kDa
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보관:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Efruxifermin
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Customer Validation & Images
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In Vivo Efficacy Study
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Histological Imaging/Staining
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RT-PCR
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WB
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IF
Biological Activity
제품 설명
Species Reactivity
Human
IC50 & Target
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FGFR1 |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male and female Sprague Dawley rats[1]
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Dosage:0, 1, 10, 30, 100 mg/kg
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Administration:Subcutaneous injection, Once weekly, for 4 or 26 weeks
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Result:Significantly reduced body weight gain after 4 and 26 weeks, despite increasing food intake. Markers of sympathetic activation, urinary corticosterone and ratio of adrenal-to-body weight were unchanged.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IGHG1 Fc (Fragment constant)-[FGF21 (fibroblast growth factor 21)]2
Verified Bioactivity
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Loaded Efruxifermin on Protein A Chip, can bind Klotho beta Protein, Human (HEK293, His, HY-P77972) with an affinity constant of 2.21E-08 M as determined in SPR assay.
Chemical Information
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CAS No. 2375240-92-7
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Appearance Liquid
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분자량 91.863 kDa
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Color Colorless to light yellow
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SMILES
[Efruxifermin]
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Synonyms
AKR-001; AMG-876
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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J Adv Res
FGF21-FGFR1 signaling protects against cardiac hypertrophy by regulating PINK1-mediated mitophagy pathway. [Abstract]2025 Oct 29:S2090-1232(25)00848-3. PMID: 41173187
Efruxifermin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3. [Abstract]
Efruxifermin (FGF21; 1 mg/kg; subcutaneous injection). Measurement of LVEF in the indicated groups.
Efruxifermin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3. [Abstract]
Efruxifermin (FGF21; 1 mg/kg; subcutaneous injection). Representative image of HE staining.
Efruxifermin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3. [Abstract]
Efruxifermin (FGF21; 1 mg/kg; subcutaneous injection). ANP and BNP mRNA levels in the indicated group.
Efruxifermin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3. [Abstract]
Efruxifermin (FGF21; 1 mg/kg; subcutaneous injection). ANP and BNP protein levels in the indicated group.
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Research (Wash D C)
Fibroblast Growth Factor 21 Promotes Vascular Smooth Muscle Cell Contractile Polarization via p38 Mitogen-Activated Protein Kinase-Promoted Serum Response Factor Phosphorylation. [Abstract]2025 Aug 5:8:0815. PMID: 40765997
Efruxifermin purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2025 Aug 5:8:0815. [Abstract]
Efruxifermin (5 mg/kg; subcutaneous injection). The expression of SMA and OPN in SMA-positive cells in neointimal areas was determined by immunofluorescence staining.
순도&문서
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Efruxifermin Related Classifications
HY-P99930 Related Classifications
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