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Cat. No.: HY-184150

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EN10

EN10 is a ligand for the muscle-specific E3 ligase KLHL41, which can be used to synthesize PROTAC KBD-1 (HY-184151) targeting BRD4.

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CAS No.: 2093466-80-7
화학식: C₂₁H₂₃N₃O
분자량:333.43

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

EN10 Chemical Structure

CAS No.: 2093466-80-7

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

EN10 is a ligand for the muscle-specific E3 ligase KLHL41, which can be used to synthesize PROTAC KBD-1 (HY-184151) targeting BRD4^[1].

IC₅₀ & Target^[1]

KLHL41

All Ligands for E3 Ligase Isoforms :

In Vitro

EN10 (5-15 μM; 30 min) selectively binds to KLHL41 (but not KLHL40) in live RH30 human muscle rhabdomyosarcoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2093466-80-7
분자량 333.43
화학식 C₂₁H₂₃N₃O
SMILES

[C@@H]1(C2=CC=CC=C2)OCC[C@H]1CNCC3=CNN=C3C4=CC=CC=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Yim J, et al. Discovery of a KLHL41 Ligand for Muscle Specific Protein Degradation. Nat Commun. 2026;17(1):4551. Published 2026 May 26. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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EN10

All Ligands for E3 Ligase Isoforms