COMMD1 - copper metabolism domain containing 1 Gene

Also Known as MURR1; C2orf5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 150684

About COMMD1

Cytogenetic location: 2p15 Genomic coordinates (GRCh38): 2:61,888,391-62,136,058 (from NCBI)

This gene has 8 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in heart (RPKM 5.7), testis (RPKM 5.6) and 25 other tissues.

Summary

COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]

COMMD1 Products (4)

mRNA	Protein	Name
NM_001321781.3	NP_001308710.1	COMM domain-containing protein 1 isoform 2
NM_001321782.3	NP_001308711.1	COMM domain-containing protein 1 isoform 2
NM_001371765.2	NP_001358694.1	COMM domain-containing protein 1 isoform 2
NM_152516.4	NP_689729.1	COMM domain-containing protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables copper ion binding	IDA IDA: Inferred from direct assay	17309234	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15799966	GOA
enables phosphatidic acid binding	IDA IDA: Inferred from direct assay	18940794	GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	18940794	GOA
enables phosphatidylinositol-3,4-bisphosphate binding	IDA IDA: Inferred from direct assay	18940794	GOA
enables phosphatidylinositol-3,5-bisphosphate binding	IDA IDA: Inferred from direct assay	18940794	GOA
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	18940794	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12968035	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	15799966	GOA
enables sodium channel inhibitor activity	IDA IDA: Inferred from direct assay	14645214	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi to plasma membrane transport	IMP IMP: Inferred from mutant phenotype	25355947	GOA
involved in copper ion homeostasis	IDA IDA: Inferred from direct assay	14685266	GOA
acts upstream of or within negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	16573520	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	15799966	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	17183367	GOA
involved in negative regulation of protein localization to cell surface	IDA IDA: Inferred from direct assay	21741370	GOA
involved in negative regulation of sodium ion transmembrane transport	IDA IDA: Inferred from direct assay	14645214	GOA
involved in negative regulation of sodium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	20237237	GOA
involved in nucleotide-excision repair	IMP IMP: Inferred from mutant phenotype	23144634	GOA
involved in plasma membrane to endosome transport	IDA IDA: Inferred from direct assay	21741370	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	17183367	GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	17183367	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cul2-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	17183367	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	14685266	GOA
located in early endosome	IDA IDA: Inferred from direct assay	25355947	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15799966	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	21741370	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COMMD1 Protein Structure

COMM_domain

0
100
190 a.a.

Protein Preferred Names	Protein Names
COMM domain-containing protein 1	copper metabolism (Murr1) domain containing 1

COMMD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	COMMD1	Q8N668	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	37172566
Intra	COMMD1	Q8N668	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	33961781
Intra	COMMD1	Q8N668	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	28514442
Intra	COMMD1	Q8N668	CCDC93	Homo sapiens	Q567U6	Anti Bait CoIP	25355947
Intra	COMMD1	Q8N668	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	35271311
Intra	COMMD1	Q8N668	CCDC93	Homo sapiens	Q567U6	Pull Down	25355947
Intra	COMMD1	Q8N668	CCDC93	Homo sapiens	Q567U6	Confocal	25355947
Intra	COMMD1	Q8N668	ATP7B	Homo sapiens	P35670	Pull Down	12968035
Intra	COMMD1	Q8N668	ATP7B	Homo sapiens	P35670	Confocal	17919502
Intra	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	Anti Tag CoIP	37172566
Intra	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	Anti Tag CoIP	33961781
Intra	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	Anti Tag CoIP	28514442
Intra	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	TAP	23563313
Intra	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	Pull Down	15799966
Intra	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	TAP	15799966
Intra	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	Anti Tag CoIP	35271311
Intra	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	GMS	37172566
Intra	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	3D-EM	37172566
Intra	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Anti Tag CoIP	35271311
Intra	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Y2H Array	25416956
Intra	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Pull Down	15799966
Intra	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Y2H Array	32296183
Intra	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Validated Y2H	25416956
Intra	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Anti Tag CoIP	37172566
Intra	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	TAP	23563313
Intra	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	3D-EM	37172566
Intra	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Anti Tag CoIP	33961781
Intra	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Anti Bait CoIP	23563313
Intra	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	GMS	37172566
Intra	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Y2H Prey Pooling	25416956
Intra	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	TAP	15799966
Intra	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Y2H Prey Pooling	32296183
Intra	COMMD1	Q8N668	CCDC22	Homo sapiens	O60826	Anti Bait CoIP	23563313
Intra	COMMD1	Q8N668	COMMD2	Homo sapiens	Q86X83	Anti Tag CoIP	28514442
Intra	COMMD1	Q8N668	COMMD2	Homo sapiens	Q86X83	3D-EM	37172566
Intra	COMMD1	Q8N668	COMMD2	Homo sapiens	Q86X83	Anti Tag CoIP	35271311
Intra	COMMD1	Q8N668	COMMD2	Homo sapiens	Q86X83	Anti Tag CoIP	33961781
Intra	COMMD1	Q8N668	COMMD2	Homo sapiens	Q86X83	Anti Tag CoIP	37172566
Intra	COMMD1	Q8N668	COMMD5	Homo sapiens	Q9GZQ3	Anti Tag CoIP	33961781
Intra	COMMD1	Q8N668	COMMD5	Homo sapiens	Q9GZQ3	Anti Tag CoIP	28514442
Intra	COMMD1	Q8N668	COMMD5	Homo sapiens	Q9GZQ3	Anti Tag CoIP	35271311
Intra	COMMD1	Q8N668	COMMD5	Homo sapiens	Q9GZQ3	3D-EM	37172566
Intra	COMMD1	Q8N668	COMMD5	Homo sapiens	Q9GZQ3	Anti Tag CoIP	37172566
Intra	COMMD1	Q8N668	COMMD5	Homo sapiens	Q9GZQ3	Pull Down	15799966
Intra	COMMD1	Q8N668	COMMD7	Homo sapiens	Q86VX2	Anti Tag CoIP	33961781
Intra	COMMD1	Q8N668	COMMD7	Homo sapiens	Q86VX2	3D-EM	37172566
Intra	COMMD1	Q8N668	COMMD7	Homo sapiens	Q86VX2	Pull Down	15799966
Intra	COMMD1	Q8N668	COMMD7	Homo sapiens	Q86VX2	Anti Tag CoIP	35271311
Intra	COMMD1	Q8N668	COMMD10	Homo sapiens	Q9Y6G5	3D-EM	37172566
Intra	COMMD1	Q8N668	COMMD10	Homo sapiens	Q9Y6G5	Anti Tag CoIP	33961781
Intra	COMMD1	Q8N668	COMMD10	Homo sapiens	Q9Y6G5	Anti Tag CoIP	28514442
Intra	COMMD1	Q8N668	COMMD10	Homo sapiens	Q9Y6G5	Anti Tag CoIP	37172566
Intra	COMMD1	Q8N668	COMMD10	Homo sapiens	Q9Y6G5	Pull Down	15799966
Intra	COMMD1	Q8N668	COMMD10	Homo sapiens	Q9Y6G5	Anti Tag CoIP	35271311
Intra	COMMD1	Q8N668	TCEAL8	Homo sapiens	Q8IYN2	Y2H Prey Pooling	32296183
Intra	COMMD1	Q8N668	TCEAL8	Homo sapiens	Q8IYN2	Y2H Array	32296183
Intra	COMMD1	Q8N668	SCNN1D	Homo sapiens	P51172	Pull Down	14645214
Intra	COMMD1	Q8N668	ELOC	Homo sapiens	Q15369	Pull Down	23563313
Intra	COMMD1	Q8N668	ELOC	Homo sapiens	Q15369	Pull Down	17183367
Intra	COMMD1	Q8N668	REL	Homo sapiens	Q04864	Anti Bait CoIP	15799966
Intra	COMMD1	Q8N668	REL	Homo sapiens	Q04864	Pull Down	15799966
Intra	COMMD1	Q8N668	NFKBIA	Homo sapiens	P25963	Anti Tag CoIP	14685242
Intra	COMMD1	Q8N668	RELB	Homo sapiens	Q01201	Pull Down	15799966
Intra	COMMD1	Q8N668	CUL2	Homo sapiens	Q13617	Pull Down	23563313
Intra	COMMD1	Q8N668	CUL2	Homo sapiens	Q13617	Pull Down	17183367
Intra	COMMD1	Q8N668	COMMD3	Homo sapiens	Q9UBI1	3D-EM	37172566
Intra	COMMD1	Q8N668	COMMD3	Homo sapiens	Q9UBI1	Anti Tag CoIP	33961781
Intra	COMMD1	Q8N668	COMMD3	Homo sapiens	Q9UBI1	Anti Tag CoIP	28514442
Intra	COMMD1	Q8N668	COMMD3	Homo sapiens	Q9UBI1	TAP	23563313
Intra	COMMD1	Q8N668	COMMD3	Homo sapiens	Q9UBI1	TAP	15799966
Intra	COMMD1	Q8N668	COMMD3	Homo sapiens	Q9UBI1	Anti Tag CoIP	37172566
Intra	COMMD1	Q8N668	COMMD8	Homo sapiens	Q9NX08	Anti Tag CoIP	37172566
Intra	COMMD1	Q8N668	COMMD8	Homo sapiens	Q9NX08	Pull Down	15799966
Intra	COMMD1	Q8N668	COMMD8	Homo sapiens	Q9NX08	Anti Tag CoIP	28514442
Intra	COMMD1	Q8N668	COMMD8	Homo sapiens	Q9NX08	3D-EM	37172566
Intra	COMMD1	Q8N668	COMMD8	Homo sapiens	Q9NX08	Anti Tag CoIP	33961781
Intra	COMMD1	Q8N668	COMMD8	Homo sapiens	Q9NX08	GMS	37172566
Intra	COMMD1	Q8N668	COMMD8	Homo sapiens	Q9NX08	Anti Tag CoIP	35271311
Intra	COMMD1	Q8N668	RELA	Homo sapiens	Q04206	Anti Bait CoIP	15799966
Intra	COMMD1	Q8N668	RELA	Homo sapiens	Q04206	Pull Down	15799966
Intra	COMMD1	Q8N668	UPRT	Homo sapiens	Q96BW1	Validated Y2H	32296183
Intra	COMMD1	Q8N668	SOCS1	Homo sapiens	O15524	Pull Down	17183367

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Wilson Disease	Hepatolenticular Degeneration WD Wilson'S Disease WND Westphal-Strumpell Syndrome Copper Storage Disease Cerebral Pseudosclerosis Westphal Pseudosclerosis Hepatolenticular Degeneration Syndrome Copper Retention Hepatocerebral Degeneration Kinnier-Wilson Disease Neurohepatic Degeneration Progressive Hepatolenticular Degeneration Lenticular Degenerative Disease Wilson'S Syndrome Lenticular Syndrome
Nephrotic Syndrome, Type 20	NPHS20 Nephrotic Syndrome Type 20 Nephrotic Syndrome 20
Peroxisome Biogenesis Disorder 11a	PBD11A Peroxisome Biogenesis Disorder Complementation Group 13 PBD-CG13 Cg13 Pbd-Cgh Peroxisome Biogenesis Disorder Complementation Group H Peroxisome Biogenesis Disorder, Type 11a Peroxisome Biogenesis Disorder, Complementation Group 13
Retinitis Pigmentosa 28	RP28 Retinitis Pigmentosa, Type 28
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Menkes Disease	Copper Transport Disease Menkes Syndrome MNK Kinky Hair Disease Steely Hair Disease Menkes Kinky-Hair Syndrome Mk Steely Hair Syndrome Menkea Syndrome Md Menkes Kinky Hair Syndrome Hypocupremia, Congenital Kinky Hair Syndrome X-Linked Copper Deficiency Menkes Kinky Hair Disease
Metal Metabolism Disorder	Metal Metabolism, Inborn Errors Inborn Metal Metabolism Disorder
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Aceruloplasminemia	Cerebellar Ataxia Hypoceruloplasminemia Hemosiderosis, Systemic, Due To Aceruloplasminemia Familial Apoceruloplasmin Deficiency Hereditary Ceruloplasmin Deficiency Deficiency Of Ferroxidase Hypoceruloplasminemia, Hereditary Ceruloplasmin Deficiency Systemic Hemosiderosis Due To Aceruloplasminemia ACERULOP

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-P11115	CIGB-552		98.66%	Unkown
HY-P11115A	CIGB-552 TFA		/	Unkown
HY-RS03009	COMMD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21109	Commd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27628	Commd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	COMMD1	RGD	RGD:1311771
Bos taurus	COMMD1	VGNC	VGNC:27581
Canis familiaris	COMMD1	VGNC	VGNC:39491
Felis catus	COMMD1	VGNC	VGNC:61074
Mus musculus	COMMD1	MGD	MGI:109474
Macaca mulatta	COMMD1	VGNC	VGNC:82130
Others	COMMD1	NCBI