PTGES - prostaglandin E synthase Gene

Also Known as PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9536

About PTGES

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:129,738,349-129,753,042 (from NCBI)

This gene has 2 transcripts (splice variants), 197 orthologues and 1 paralogue. Biased expression in placenta (RPKM 28.7), urinary bladder (RPKM 13.8) and 12 other tissues.

Summary

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced Apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

PTGES Products (1)

mRNA	Protein	Name
NM_004878.5	NP_004869.1	prostaglandin E synthase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glutathione binding	IDA IDA: Inferred from direct assay	18682561	GOA
enables glutathione peroxidase activity	IDA IDA: Inferred from direct assay	12244105	GOA
enables glutathione transferase activity	IDA IDA: Inferred from direct assay	12672824	GOA
enables prostaglandin-E synthase activity	IDA IDA: Inferred from direct assay	18682561	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in prostaglandin biosynthetic process	IDA IDA: Inferred from direct assay	18682561	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	18682561	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGES Protein Structure

MAPEG

0
100
152 a.a.

Protein Preferred Names	Protein Names
prostaglandin E synthase	MGST1-like 1

PTGES Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PTGES	O14684	VAPB	Homo sapiens	O95292	Validated Y2H	32296183
Intra	PTGES	O14684	GIMAP1	Homo sapiens	Q8WWP7	Validated Y2H	32296183
Intra	PTGES	O14684	C4orf3	Homo sapiens	Q8WVX3-2	Validated Y2H	32296183
Intra	PTGES	O14684	EHHADH	Homo sapiens	Q08426	Y2H Array	32296183
Intra	PTGES	O14684	EHHADH	Homo sapiens	Q08426	Validated Y2H	32296183
Intra	PTGES	O14684	YIF1A	Homo sapiens	O95070	Validated Y2H	32296183
Intra	PTGES	O14684	TMEM222	Homo sapiens	Q9H0R3	Validated Y2H	32296183
Intra	PTGES	O14684	PLP2	Homo sapiens	Q04941	Validated Y2H	32296183
Intra	PTGES	O14684	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	PTGES	O14684	TMEM65	Homo sapiens	Q6PI78	Validated Y2H	32296183
Intra	PTGES	O14684	VAMP3	Homo sapiens	Q15836	Validated Y2H	32296183
Intra	PTGES	O14684	TMEM19	Homo sapiens	Q96HH6	Validated Y2H	32296183
Intra	PTGES	O14684	VAMP4	Homo sapiens	O75379	Validated Y2H	32296183
Intra	PTGES	O14684	BET1	Homo sapiens	O15155	Validated Y2H	32296183
Intra	PTGES	O14684	SERP2	Homo sapiens	Q8N6R1	Validated Y2H	32296183
Intra	PTGES	O14684	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	PTGES	O14684	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

PTGES Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P81996	Prostaglandin E Synthase Antibody (YA1741)	WB	Human, Mouse, Rat
HY-P81996A	Prostaglandin E Synthase Antibody (YA1741)(PBS only)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Gastric Ulcer	Stomach Ulcer Acute Gastric Ulcer With Haemorrhage And Perforation Acute Gastric Ulcer With Hemorrhage And Obstruction Acute Gastric Ulcer With Hemorrhage And Perforation Acute Gastric Ulcer With Hemorrhage And Perforation, With Obstruction Acute Gastric Ulcer With Hemorrhage And Perforation, Without Mention Of Obstruction Acute Gastric Ulcer With Hemorrhage And With Perforation But Without Obstruction Acute Gastric Ulcer With Hemorrhage, With Obstruction Acute Gastric Ulcer With Hemorrhage, With Perforation And With Obstruction Acute Gastric Ulcer With Perforation Acute Gastric Ulcer With Perforation And Obstruction Acute Gastric Ulcer With Perforation, With Obstruction Acute Gastric Ulcer Without Hemorrhage And Without Perforation Acute Gastric Ulcer Without Hemorrhage, Without Perforation And Without Obstruction Acute Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction Bleeding Acute Gastric Ulcer Chronic Gastric Ulcer Without Hemorrhage And Without Perforation Chronic Gastric Ulcer Without Hemorrhage And Without Perforation But With Obstruction Chronic Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, With Obstruction Gastric Ulcers Cushings Ulcer Cushing'S Ulcer Of Stomach Peptic Ulcer Of Stomach Mucosal Defect Of The Stomach
Gastritis	Acute Gastric Mucosal Erosion Erosive Gastritis Erosive Gastropathy Gastritis Erosive Idiopathic Erosive/Hemorrhagic Gastritis Inflammation Of Gastric Mucosa Gastroduodenitis Gastritis Nos Noninfectious Gastroenteritis Nonbacterial Gastroenteritis Of Infant Acute Gastric Infection Acute Simple Gastritis Chronic Antral Gastritis Chronic Fundal Gastritis Chronic Simple Gastritis Acute Gastroduodenitis Acute Antral Gastritis Acute Erosive Gastritis Bile Reflux Gastritis Gastritis Due To Biliary Reflux
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Endometrial Disease	Endometrial Disorder Endometrial Diseases
Diamond-Blackfan Anemia 1	Aase Syndrome DBA1 Erythrogenesis Imperfecta Aase-Smith Syndrome Ii Dba Blackfan-Diamond Syndrome Bds Anemia, Congenital Hypoplastic, Of Blackfan And Diamond Anemia, Congenital Erythroid Hypoplastic Red Cell Aplasia, Pure, Hereditary Aregenerative Anemia, Chronic Congenital Rps19-Related Diamond-Blackfan Anemia Chronic Congenital Aregenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Pure Hereditary Red Cell Aplasia Anemia, Diamond-Blackfan, Type 1 Anemia, Diamond-Blackfan Aase Smith Syndrome 2 Familial Hypoplastic Anaemia With Malformations Constitutional Pure Red Cell Aplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS11379	PTGES Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11380	PTGES2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11381	PTGES3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19734	Ptges Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19804	Ptges2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19805	Ptges3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26230	Ptges Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26300	Ptges2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26301	Ptges3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PTGES	MGD	MGI:1927593
Canis familiaris	PTGES	VGNC	VGNC:45145
Rattus norvegicus	PTGES	RGD	RGD:62076
Macaca mulatta	PTGES	VGNC	VGNC:76471
Felis catus	PTGES	VGNC	VGNC:69142
Bos taurus	PTGES	VGNC	VGNC:33505
Others	PTGES	NCBI