GRL-8234
GRL-8234 is a potent β-secretase (BACE1) inhibitor with blood-brain barrier penetration (Ki = 1.8 nM). GRL-8234 can rescue age-related cognitive decline in Tg2576 mice. GRL-8234 can be used in the research related to Alzheimer's disease (AD).
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- CAS No.: 913071-81-5
- 화학식: C36H42N4O6S
- 분자량:658.81
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
0.001 μM
Compound: 24, GRL-8234
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Inhibition of memapsin 2 expressed in CHO cells
Inhibition of memapsin 2 expressed in CHO cells
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[PMID: 18180160] |
Chemical Information
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CAS No. 913071-81-5
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분자량 658.81
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화학식 C36H42N4O6S
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SMILES
O=S(N(C)C1=CC(C(N[C@@H](CC2=CC=CC=C2)[C@@H](CNCC3=CC(OC)=CC=C3)O)=O)=CC(C(N[C@H](C)C4=CC=CC=C4)=O)=C1)(C)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GRL-8234 Related Classifications
HY-10104 Related Classifications
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