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Cat. No.: HY-184786

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Tyk2-IN-14

Tyk2-IN-14 is a Tyk2 inhibitor that regulates IFNα and IL-23 by inhibiting Tyk2-mediated signal transduction. Tyk2-IN-14 exhibits an IC₅₀ of 0.08 μM against the IL-23 Kit225 reporter gene and an IC₅₀ of 0.09 μM against the IFNα Kit225 reporter gene. IL-23 modulator-1 is applicable to the research of inflammatory diseases and autoimmune diseases.

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CAS No.: 1609392-06-4
화학식: C₁₈H₁₈N₆O₃S
분자량:398.44

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tyk2-IN-14 Chemical Structure

CAS No.: 1609392-06-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
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Calculators
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

Tyk2	IL-23 0.08 μM (IC₅₀)

All JAK Isoforms :

All Interleukin Related Isoforms :

In Vitro

Tyk2-IN-14 (CPD31) inhibits IL-23-induced reporter gene activity in Kit225 T cells with an IC₅₀ of 0.08 μM; it also inhibits IFNα-induced reporter gene activity in Kit225 T cells with an IC₅₀ of 0.09 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1609392-06-4
분자량 398.44
화학식 C₁₈H₁₈N₆O₃S
SMILES

O=C(NC)C1=NN=C(C=C1NC=2C=CC=CC2S(=O)(=O)C)NC3=NC=CC=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Moslin R M, et al. AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES. WO2014074661A1. WIPO. 2014.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- IC₅₀ & Target
- In Vitro
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Tyk2-IN-14

All JAK Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Tyk2-IN-14 Related Classifications

HY-184786 Related Classifications