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Cat. No.: HY-170428

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IPS-06061

IPS-06061 is an orally active molecular glue forming a ternary complex of CRBN-KRAS^G12D-IPS06061, degrading KRAS^G12D with a DC₅₀ value lower than 500 nM. IPS-06061 shows a strong anti-tumor efficacy.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3064065-83-1
화학식: C₂₁H₂₅NO₃
분자량:339.43

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

IPS-06061 Chemical Structure

CAS No.: 3064065-83-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[2]

KRas G12D

<500 nM (DC₅₀)

Cereblon

All Ras Isoforms :

All Ligands for E3 Ligase Isoforms :

In Vivo

IPS-06061 shows a strong anti-tumor efficacy using a xenograftanimal model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3064065-83-1
분자량 339.43
화학식 C₂₁H₂₅NO₃
SMILES

O=C(OCC)[C@@H](N[C@H](C(C1=CC=CC=C1)=O)C)CCC2=CC=CC=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kang I, et al. IPS-06061, a novel TPD molecular glue degrader targeting KRAS G12D[J]. Cancer Research, 2025, 85(8_Supplement_1): 384-384.

[2]. Xu YX, et al. A Comprehensive Review of Marketed KRAS Inhibitors and Degraders: Challenges and Opportunities. Med Res Rev. Published online February 9, 2026. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

IPS-06061

All Ras Isoforms

All Ligands for E3 Ligase Isoforms