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Cat. No.: HY-169634

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JD118

Name: JD118
Brand: MedChemExpress
SKU: HY-169634
Price: 137.00 USD
Availability: InStock
Rating: 5 (1 reviews)

JD118 is a JNK inhibitor. JD118 inhibits JNK1 activity and the expression of cJun (1–135).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 315704-83-7
화학식: C₁₃H₁₂N₄S₂
분자량:288.39

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

JD118 Chemical Structure

CAS No.: 315704-83-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

JD118 is a JNK inhibitor. JD118 inhibits JNK1 activity and the expression of cJun (1–135)^[1].

All JNK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	44 μM Compound: 7	Antiproliferative activity against MCF7 cells after 72 hrs Antiproliferative activity against MCF7 cells after 72 hrs	[PMID: 17223347]
SK-BR-3	IC₅₀	55 μM Compound: 7	Antiproliferative activity against SkBr3 cells after 72 hrs Antiproliferative activity against SkBr3 cells after 72 hrs	[PMID: 17223347]
SK-BR-3	IC₅₀	61 μM Compound: 7	Induction of Hsp90-dependent Her2 protein degradation in Skbr3 cells after 24 hrs by ELISA Induction of Hsp90-dependent Her2 protein degradation in Skbr3 cells after 24 hrs by ELISA	[PMID: 17223347]

Chemical Information

CAS No. 315704-83-7
분자량 288.39
화학식 C₁₃H₁₂N₄S₂
SMILES

CC1=C(SC(N)=N1)C2=CSC(NC3=CC=CC=C3)=N2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ngoei KR, et al. Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds. Biochim Biophys Acta. 2013;1834(6):1077-1088. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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