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Cat. No.: HY-N9376

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Kansuinine E

Kansuinine E is a plant-derived nitric oxide inhibitor (IC₅₀=6.3 μM). Kansuinine E belongs to jatrophane-type diterpenoids and is isolated from the roots of E. kansui.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 672945-84-5
화학식: C₄₁H₄₇NO₁₄
분자량:777.81

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Kansuinine E Chemical Structure

CAS No.: 672945-84-5

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocol (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Kansuinine E is a plant-derived nitric oxide inhibitor (IC₅₀=6.3 μM). Kansuinine E belongs to jatrophane-type diterpenoids and is isolated from the roots of E. kansui^[1].

IC₅₀ & Target

IC50: 6.3 μM (nitric oxide)^[1].

All NO Synthase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
NIH3T3	ED₅₀	>50 μg/mL Compound: 5, kansuinin E	Survival effect on NGF-dependent mouse NIH/3T3 cells expressing TrkB assessed as cell viability after 2 days by MTT assay Survival effect on NGF-dependent mouse NIH/3T3 cells expressing TrkB assessed as cell viability after 2 days by MTT assay	[PMID: 15387657]
NIH3T3	ED₅₀	0.23 μg/mL Compound: 5, kansuinin E	Survival effect on NGF-dependent mouse NIH/3T3 cells expressing TrkA assessed as cell viability after 2 days by MTT assay Survival effect on NGF-dependent mouse NIH/3T3 cells expressing TrkA assessed as cell viability after 2 days by MTT assay	[PMID: 15387657]

Chemical Information

CAS No. 672945-84-5
분자량 777.81
화학식 C₄₁H₄₇NO₁₄
SMILES

C[C@H]1C[C@@]2(OC(C)=O)[C@@H]([C@@H](OC(C)=O)C([C@H](OC(C)=O)[C@@H](OC(C3=CC=CC=C3)=O)[C@@H](OC(C4=CN=CC=C4)=O)C(C)(C)[C@@H]5[C@H]([C@@H](C)C2=O)O5)=C)[C@H]1OC(C)=O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lee JW, et al. Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells. Bioorg Med Chem Lett. 2016;26(14):3351-3354. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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