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Cat. No.: HY-19418

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KRP-101

KRP-101 is a compound that regulates the expression of genes related to lipid metabolism. It is a PPARα agonist that can highly sensitively regulate the expression of genes such as apolipoprotein A-IV, which may be related to lowering serum triglycerides and increasing HDL.

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CAS No.: 311770-26-0
화학식: C₂₆H₂₆FNO₅
분자량:451.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

KRP-101 Chemical Structure

CAS No.: 311770-26-0

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All PPAR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	0.014 μM Compound: 7	Transcriptional activation activity on human T279M-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells Transcriptional activation activity on human T279M-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells	[PMID: 12951082]
CHO-K1	EC₅₀	0.667 μM Compound: 7	Transcriptional activation activity on human I272F-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells Transcriptional activation activity on human I272F-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells	[PMID: 12951082]
CHO-K1	EC₅₀	0.00061 μM Compound: 7	Transcriptional activation activity on human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells Transcriptional activation activity on human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells	[PMID: 12951082]
CHO-K1	EC₅₀	0.61 nM Compound: 7	Transcriptional activation activity on human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells Transcriptional activation activity on human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells	[PMID: 12951082]
CHO-K1	EC₅₀	0.013 μM Compound: KRP-101	Transactivation of human PPARalpha expressed in CHO-K1 cells Transactivation of human PPARalpha expressed in CHO-K1 cells	[PMID: 22133631]
CHO-K1	EC₅₀	1.92 μM Compound: KRP-101	Transactivation of human PPARdelta expressed in CHO-K1 cells Transactivation of human PPARdelta expressed in CHO-K1 cells	[PMID: 22133631]
CHO-K1	EC₅₀	2.5 μM Compound: KRP-101	Transactivation of human PPARgamma expressed in CHO-K1 cells Transactivation of human PPARgamma expressed in CHO-K1 cells	[PMID: 22133631]

Chemical Information

CAS No. 311770-26-0
분자량 451.49
화학식 C₂₆H₂₆FNO₅
SMILES

FC(C=C1)=CC=C1OC(C=C2)=CC=C2CNC(C3=C(C=CC(C[C@H](CC)C(O)=O)=C3)OC)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Highly sensitive upregulation of apolipoprotein A-IV by peroxisome proliferator-activated receptor alpha (PPARalpha) agonist in human hepatoma cells

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
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수량:
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KRP-101

All PPAR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

KRP-101 Related Classifications

HY-19418 Related Classifications