Laminaran
Based on 2 publication(s) in Google Scholar
Laminaran is an β-1-3-glucan and a typical ligand for Dectin-1 from Eisenia Bicyclis, has potent immunomodulating, radioprotective, and anticancer activities. Laminaran is made up of β (1→3)-glucan with β (1→6)-branches and can be catalyzed by enzymes such as laminarinase (EC 3.2.1.6) that breaks the β (1→3) bonds. Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy.
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- CAS No.: 9008-22-4
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) Laminaran
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Biological Activity
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Dectin-1 |
Laminaran (100-800 μg/mL; 24 hours) is not cytotoxic against normal epidermal cells JB6 Cl41 and human melanoma cells SK-MEL-28, the percentage of inhibition of living cells number is less than 15 % at concentrations range up to 800 μg/mL after 24 h of treatment[1]. Laminaran (200 μg/mL; 24-72 hours)does not cause any growth inhibition of SK-MEL-28 cells after 24 and 48 h of treatment, but decreases cells proliferation by 36 % after 72 h of treatment[1]. Laminaran (25-50 μg/mL; 24 hours) at low concentration does not influence the phosphorylation of c-Raf (Ser259), ERK1/2 (Tyr202/Tyr204), and MEK1/2 (Ser 221) kinases as well as total expression level of investigated proteins. But decreases p-MEK, p-ERK1/2 at 50 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:JB6 Cl41 and SK-MEL-28 cells
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Concentration:100, 200, 400, and 800 µg/mL
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Incubation Time:24 hours
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Result:Showed no cytotoxic against normal epidermal cells JB6 Cl41 and human melanoma cells SK-MEL-28.
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Cell Line:SK-MEL-28 cells
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Concentration:200 µg/mL
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Incubation Time:24 hours
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Result:Decreased cell proliferation at 72 hours.
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Cell Line:SK-MEL-28 cells
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Concentration:25 µg/mL; 50 µg/mL
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Incubation Time:24 hours
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Result:Inhibited phosphorylation of c-Raf, MEK1/2, and ERK1/2 kinases.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice injected s.c. with B16-OVA cells[3]
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Dosage:12.5, 25, and 50 mg/kg; 21 days
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Administration:Intravenous injection
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Result:Prevented B16-OVA tumor growth by inducing Ag-specific immune responses.
Chemical Information
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CAS No. 9008-22-4
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Appearance Solid
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Color White to off-white
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SMILES
[Laminaran]
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Int Immunopharmacol
2025 Jan 9:147:114014. PMID: 39793225
Laminaran purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 9:147:114014. [Abstract]
Laminaran (100 μM) treatment significantly increased the HTDNA-induced expression of IFNB in Hela cells.
Laminaran purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 9:147:114014. [Abstract]
Laminaran (50-500 µM; 6 h) increased mRNA expression level of IFNB in THP-1 cells stimulated with HTDNA.
Laminaran purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 9:147:114014. [Abstract]
Laminaran (100 µM; 6 h) increased IFN-β production in THP-1 cells stimulated with HTDNA.
Laminaran purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 9:147:114014. [Abstract]
Laminaran (100 µM; 6 h) increased mRNA expression levels of CXCL10 and ISG56 in THP-1 cells stimulated with HTDNA.
Laminaran purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 9:147:114014. [Abstract]
Laminaran (25 mg/kg; i.v.; once daily for 3 weeks) decreased inflammatory cell infiltration and tissue damage in the lung of C57BL/6J mice after HSV-1 infection.
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용액&용해도
H2O : 16.67 mg/mL (Need ultrasonic)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 33.33 mg/mL; Clear solution; Need ultrasonic
순도&문서
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Data Sheet (273 KB)
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SDS (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Malyarenko OS, et al. Laminaran from brown alga Dictyota dichotoma and its sulfated derivative as radioprotectors and radiosensitizers in melanoma therapy.Carbohydr Polym. 2019 Feb 15;206:539-547. [Content Brief]
[2]. Laminaran
[3]. Song K, et al. Laminarin promotes anti-cancer immunity by the maturation of dendritic cells.Oncotarget. 2017 Jun 13;8(24):38554-38567. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Laminaran Related Classifications
HY-119109 Related Classifications
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