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United States

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Cat. No.: HY-180575

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LCB-2122

LCB-2122 is an adenosine-like nucleoside analogue bearing a C2'-stereogenic all-carbon quaternary center. LCB-2122 can prevent Doxorubicin (HY-15142A)-induced cardiomyocytes apoptosis with an IC₅₀ of 0.5 μM and prevent Imatinib (HY-15463)-induced apoptosis. LCB-2122 can activate AMPK signaling and induce the phosphorylation of AMPK and its downstream substrate, acetyl-CoA carboxylase (ACC). LCB-2122 can reduce Doxorubicin-induced mitochondrial damage. LCB-2122 can be used for the research of heart failure.

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CAS No.: 2210298-14-7
화학식: C₁₆H₂₅ClN₅O₇P
분자량:465.83

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

LCB-2122 Chemical Structure

CAS No.: 2210298-14-7

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All AMPK Isoforms :

Chemical Information

CAS No. 2210298-14-7
분자량 465.83
화학식 C₁₆H₂₅ClN₅O₇P
SMILES

NC1=NC(Cl)=NC2=C1N=CN2[C@@H]3O[C@H](COP(OCC)(OCC)=O)[C@@H](O)[C@@]3(C)CO
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Almazloum A, et al. A Nucleoside Analogue Bearing a C2'-Stereogenic All-Carbon Quaternary Center for the Treatment of Heart Failure. J Med Chem. 2025 Dec 25;68(24):25994-26011. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
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수량:
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LCB-2122

All AMPK Isoforms

Biological Activity

제품 설명

Chemical Information

순도&문서

References

Calculators

Help & FAQs

LCB-2122 Related Classifications

HY-180575 Related Classifications

Bioz

Keywords

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