Mardepodect precursor
Mardepodect precursor is the precursor of Mardepodect (HY-50098). Mardepodect precursor. Mardepodect is a potent, selective orally active, and brain-penetrant PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs.
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- CAS No.: 871507-11-8
- 화학식: C24H18N4O
- 분자량:378.43
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
PDE10A 0.37 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
0.423 nM
Compound: 3
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Inhibition of rat recombinant PDE10A transfected in Sf9 cells
Inhibition of rat recombinant PDE10A transfected in Sf9 cells
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[PMID: 19630403] |
Chemical Information
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CAS No. 871507-11-8
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분자량 378.43
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화학식 C24H18N4O
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SMILES
C1(C2=CNN=C2C3=CC=C(OCC4=NC5=C(C=C4)C=CC=C5)C=C3)=CC=NC=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Verhoest PR, et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem, 2009, 52(16), 5188-5196. [Content Brief]
[2]. Grauer SM, et al. Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia. J Pharmacol Exp Ther, 2009, 331(2), 574-590. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mardepodect precursor Related Classifications
HY-169773 Related Classifications
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