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Cat. No.: HY-12625

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MIV-6

MIV-6 is a small molecule inhibitor that inhibits menin-mixed lineage leukemia (MLL) interaction and exhibits strong selective activity in MLL leukemia cells with IC₅₀ = 56 nM.

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CAS No.: 1560968-27-5
화학식: C₂₇H₃₅N₃O
분자량:417.59

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

MIV-6 Chemical Structure

CAS No.: 1560968-27-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

MIV-6 is a small molecule inhibitor that inhibits menin-mixed lineage leukemia (MLL) interaction and exhibits strong selective activity in MLL leukemia cells with IC₅₀ = 56 nM.

All Epigenetic Reader Domain Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Bone marrow cell	GI₅₀	1.1 μM Compound: 19, MIV-6	Growth inhibition of mouse bone marrow cells expressing MLL-AF9 after 7 days by MTT assay Growth inhibition of mouse bone marrow cells expressing MLL-AF9 after 7 days by MTT assay	[PMID: 24472025]
MOLM-13	GI₅₀	3.7 μM Compound: 19, MIV-6	Growth inhibition of human MOLM13 cells harboring MLL-AF9 after 7 days by MTT assay Growth inhibition of human MOLM13 cells harboring MLL-AF9 after 7 days by MTT assay	[PMID: 24472025]
MV4-11	GI₅₀	2.8 μM Compound: 19, MIV-6	Growth inhibition of human MV411 cells harboring MLL-AF4 after 7 days by MTT assay Growth inhibition of human MV411 cells harboring MLL-AF4 after 7 days by MTT assay	[PMID: 24472025]
MV4-11	IC₅₀	3.6 μM Compound: 4; MIV-6	Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay	[PMID: 31244110]

Chemical Information

CAS No. 1560968-27-5
분자량 417.59
화학식 C₂₇H₃₅N₃O
SMILES

N#CC1=CC=C(OCCCN2CCC(C(C3CCCC3)(N)C4=CC=CC=C4)CC2)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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MIV-6

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

MIV-6 Related Classifications

HY-12625 Related Classifications