Nitromemantine
Nitromemantine (NitroSynapsin) is a nitrate derivative of Memantine (HY-B0591) and is a dual-functional NMDAR antagonist. Nitromemantine exhibits significant efficacy in rodent models of cerebral infarction through a dual mechanism of blocking channels and regulating receptors via NO/redox regulation. Nitromemantine can target ischemic neurons under hypoxic conditions and enhance its activity. Nitromemantine inhibits the current induced by NMDA, with its IC50 being 2.4 μM. Nitromemantine can be used for the study of cerebral ischemic stroke.
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- CAS No.: 765890-91-3
- 화학식: C14H24N2O3
- 분자량:268.35
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
Chemical Information
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CAS No. 765890-91-3
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분자량 268.35
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화학식 C14H24N2O3
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SMILES
CCC1(C2)CC3(CC)CC2(N)CC(C3)(O[N+]([O-])=O)C1
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Synonyms
NitroSynapsin; YQW-036; NMI-6979
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nitromemantine Related Classifications
HY-180370 Related Classifications
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- Nitromemantine
- 765890-91-3
- NitroSynapsin
- YQW-036
- NMI-6979
- YQW036
- YQW 036
- YQW-036
- NMI6979
- NMI 6979
- NMI-6979
- iGluR
- Drug Derivative
- NMDAR antagonist
- NitroMemantine
- cerebrovascular disease
- S-nitrosylation
- open-channel block
- neuroprotection
- hypoxia
- synaptic sparing
- ischemic stroke
- allosteric modulation
- Inhibitor
- inhibitor
- inhibit