country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-137843

Copy Link Print Information

NSC 80467

고객리뷰

Based on 1 Customer Validation

NSC 80467, a DNA damaging agent, selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and results in induction of γH2AX and pKAP1, two markers of DNA damage.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.39%
CAS No.: 101982-51-8
화학식: C₂₄H₂₂BrN₃O₅
분자량:512.35

보관:

Powder -20°C, 3 years , 4°C, 2 years

* The compound is unstable in solutions, freshly prepared is recommended.

NSC 80467 Chemical Structure

CAS No.: 101982-51-8

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

NSC 80467, a DNA damaging agent, selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and results in induction of γH2AX and pKAP1, two markers of DNA damage^[1].

All DNA/RNA Synthesis Isoforms :

In Vitro

NSC 80467 has a similar spectrum of activity against the NCI-60 cell line panel, suppresses survivin expression, shows COMPARE correlation with DNA damaging agents, preferentially inhibits DNA synthesis, and induces a DNA damage response characterized by enhanced γH2AX and pKAP1 at concentrations lower than those capable of inhibiting survivin expression^[1].
NSC 80467 (200 or 800 nM; 24 hours) inhibits surviving^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

PC3 cells
Concentration:

200 or 800 nM
Incubation Time:

24 hours
Result:

Associated with inhibition of survivin expression.

Chemical Information

CAS No. 101982-51-8
Appearance Solid
분자량 512.35
화학식 C₂₄H₂₂BrN₃O₅
Color Gray to brown
SMILES

O=C(C1=C2[N+](CC(C3=CC=C([N+]([O-])=O)C=C3)=O)=C(C)N1CC(C)C)C4=C(C=CC=C4)C2=O.[Br-]
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years

* The compound is unstable in solutions, freshly prepared is recommended.

용액&용해도

In Vitro:

DMSO : 25 mg/mL (48.79 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9518 mL

9.7590 mL

19.5179 mL

5 mM

0.3904 mL

1.9518 mL

3.9036 mL

10 mM

0.1952 mL

0.9759 mL

1.9518 mL

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Glaros TG, et al. The "survivin suppressants" NSC 80467 and YM155 induce a DNA damage response [published correction appears in Cancer Chemother Pharmacol. 2012 Nov;70(5):763-4]. Cancer Chemother Pharmacol. 2012;70(1):207-212. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9518 mL	9.7590 mL	19.5179 mL	48.7948 mL
	5 mM	0.3904 mL	1.9518 mL	3.9036 mL	9.7590 mL
	10 mM	0.1952 mL	0.9759 mL	1.9518 mL	4.8795 mL
	15 mM	0.1301 mL	0.6506 mL	1.3012 mL	3.2530 mL
	20 mM	0.0976 mL	0.4879 mL	0.9759 mL	2.4397 mL
	25 mM	0.0781 mL	0.3904 mL	0.7807 mL	1.9518 mL
	30 mM	0.0651 mL	0.3253 mL	0.6506 mL	1.6265 mL
	40 mM	0.0488 mL	0.2440 mL	0.4879 mL	1.2199 mL

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
용액&용해도
- In Vitro
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

NSC 80467

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

NSC 80467 Related Classifications

HY-137843 Related Classifications