Oleyl anilide
Based on 1 Customer Validation
Oleyl anilide (Oleic acid anilide) is a toxic agent found in some stocks of toxic oil, which is associated with toxic oil syndrome (TOS). Oleyl anilide is an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT) (IC50: 26 µM).
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- Purity: 95.2%
- CAS No.: 5429-85-6
- 화학식: C24H39NO
- 분자량:357.57
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보관:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BTI-TN-5B1-4 | IC50 |
0.14 μM
Compound: oleic acid anilide
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Inhibition of human ACAT1 expressed in Hi5 cells
Inhibition of human ACAT1 expressed in Hi5 cells
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[PMID: 16919944] |
| BTI-TN-5B1-4 | IC50 |
0.17 μM
Compound: oleic acid anilide
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Inhibition of human ACAT2 expressed in Hi5 cells
Inhibition of human ACAT2 expressed in Hi5 cells
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[PMID: 16919944] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female MRL+/+ mice[2]
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Dosage:0.8 mmol/kg
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Administration:i.p., twice a week for 6 weeks
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Result:Increaseed IgG, IgG1, IgG2a, IgG3, IgE and IgG2b levels.
Increased lymphocyte population.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 5429-85-6
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Appearance Solid
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분자량 357.57
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화학식 C24H39NO
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Color White to yellow
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SMILES
CCCCCCCC/C=C\CCCCCCCC(NC1=CC=CC=C1)=O
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Synonyms
Oleic acid anilide; OAA
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
순도&문서
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Data Sheet (262 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Roth BD, et al. Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents. J Med Chem. 1992 May 1;35(9):1609-17. [Content Brief]
[2]. Cai P, et al. Immunotoxic response of oleic acid anilide and its hydrolysis products in female MRL (+/+) mice. J Immunotoxicol. 2005 Oct 1;2(4):231-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Oleyl anilide Related Classifications
HY-114619 Related Classifications
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