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Cat. No.: HY-175004

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PBD dimer-4

PBD dimer-4 (Compound 7) is a C1-subsitituted PBD dimer. PBD dimer-4 has high DNA-binding affinity, DNA cross-linking ability and potent cytotoxicity against MDA-MB-231 cells (IC₅₀: 236 nM). PBD dimer-4 can be used as a payload of ADC Loncastuximab tesirine (HY-P99349) to treat several different cancer types.

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CAS No.: 1821339-88-1
화학식: C₃₁H₃₆N₄O₈
분자량:592.64

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PBD dimer-4 Chemical Structure

CAS No.: 1821339-88-1

Amount: USD 0.00

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Use of MCE Products

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity

제품 설명

All ADC Payloads Isoforms :

Chemical Information

CAS No. 1821339-88-1
분자량 592.64
화학식 C₃₁H₃₆N₄O₈
SMILES

[H][C@]12C=NC3=CC(OC)=C(C=C3C(N1CC[C@@H]2OCCCO[C@H]4CCN5C(C6=CC(OC)=C(C=C6N=C[C@]45[H])OC)=O)=O)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Procopiou G, et al. Synthesis of novel pyrrolobenzodiazepine (PBD) C1-substituted monomers and dimers with DNA-binding activity and cytotoxicity. Bioorg Med Chem Lett. 2025 Apr 15;119:130095. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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PBD dimer-4

All ADC Payloads Isoforms

Biological Activity

제품 설명

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PBD dimer-4 Related Classifications

HY-175004 Related Classifications

Bioz

Keywords

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