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Cat. No.: HY-P10234

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Poneratoxin

Name: Poneratoxin
Brand: MedChemExpress
SKU: HY-P10234
Availability: PreOrder

3 Cited Publications

고객리뷰

Based on 3 publication(s) in Google Scholar

Poneratoxin is the modulator for voltage-gated sodium channel (NaV, EC₅₀ for NaV1.6 and NaV1.7 is 97 nM and 2.3 µM), that lowers the voltage threshold for activation and inhibits the inactivation of channels, enhances the excitability of neurons, and leads to the transmission of pain signals.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 137084-94-7
화학식: C₁₂₉H₂₁₅N₃₃O₃₁S
분자량:2756.35

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Poneratoxin Chemical Structure

CAS No.: 137084-94-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All Sodium Channel Isoforms :

In Vivo

Poneratoxin causes immediate and long-lasting nocifensive behaviours (20 to 600 pmol, intraplantar injection, single dose) in C57BL/6 J mice model, and leads to paralysis with PD₅₀ (1 h) of 74.3 nmol/g in blowflies model (0-100 nmol/g, ip, single dose)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 J mice model^[1]
Dosage:

20 to 600 pmol
Administration:

intraplantar injection, single dose
Result:

Caused spontaneous nocifensive behaviours.

Animal Model:

blowflies model^[1]
Dosage:

0-100 nmol/g
Administration:

Ip, single dose
Result:

Caused paralysis.

Chemical Information

CAS No. 137084-94-7
분자량 2756.35
화학식 C₁₂₉H₂₁₅N₃₃O₃₁S
Sequence

Phe-Leu-Pro-Leu-Leu-Ile-Leu-Gly-Ser-Leu-Leu-Met-Thr-Pro-Pro-Val-Ile-Gln-Ala-Ile-His-Asp-Ala-Gln-Arg-NH2
Sequence Shortening

FLPLLILGSLLMTPPVIQAIHDAQR-NH2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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PLoS Biol

Amyloid precursor protein modulates cerebellar Purkinje cell activity and motor function through regulation of Nav1.6 currents. [Abstract]

2025 Nov 24;23(11):e3003513. PMID: 41284713
Sci Rep

Poneratoxin as a key tool for investigating the relationship between sodium channel hypersensitivity and impaired nerve cell function. [Abstract]

2025 Jul 16;15(1):25854. PMID: 40670556
Bioorg Med Chem

D-DARTS: an alternative method for NaV1.5 affinity molecules identification based on dual-drug affinity responsive target stability. [Abstract]

2026 Jan 1:132:118436. PMID: 41086654

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Robinson SD, et al., Ant venoms contain vertebrate-selective pain-causing sodium channel toxins. Nat Commun. 2023 May 23;14(1):2977. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Poneratoxin

3 Cited Publications

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Biological Activity
- 제품 설명
- In Vivo
Chemical Information
Publications (3)
순도&문서
References

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Poneratoxin

Publications Citing Use of MedChemExpress (MCE) Poneratoxin

All Sodium Channel Isoforms

Biological Activity

Chemical Information

Publications (3)

순도&문서

References

Calculators

Help & FAQs

Poneratoxin Related Classifications

HY-P10234 Related Classifications

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