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Cat. No.: HY-113481

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Prostaglandin E3

Name: Prostaglandin E3
Brand: MedChemExpress
SKU: HY-113481
Price: 370.00 USD
Availability: InStock
Rating: 5 (1 reviews)

고객리뷰

Based on 1 Customer Validation

Prostaglandin E3 is an eicosanoid derived from eicosapentaenoic acid. Prostaglandin E3 inhibits polarization towards M1 but promotes polarization of M2a macrophages. Prostaglandin E3 shows anti-inflammatory and anti-tumor activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.4%
CAS No.: 802-31-3
화학식: C₂₀H₃₀O₅
분자량:350.45

보관:

Solution, -20°C, 2 years

Prostaglandin E3 Chemical Structure

CAS No.: 802-31-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Prostaglandin Receptor Isoforms :

All PKA Isoforms :

All COX Isoforms :

In Vitro

Prostaglandin E3 (1-10000 nM) suppresses M1 and induces M2a marker expression in polarized macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Prostaglandin E3 (1 µmol/L; i.p.) modulates macrophage polarization towards an anti-inflammatory function in LPS (HY-D1056) (5 mg/kg)-induces acute inflammation model^[1].
Prostaglandin E3 (1 µmol/L; every 3 days for 4 weeks) shows anti-tumor activity by regulates macrophage polarization^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

5 weeks, Nude mice (BABL/c) (PC3 xenograft model)^[1]
Dosage:

1 µmol/L for 50 µL
Administration:

Injected next to the tumour, every 3 days for 4 weeks
Result:

Decreased the weights of transplanted tumours, inhibits the expression of CD68 and CD206.

Animal Model:

6-8-week-old C57BL6/J mice^[1]
Dosage:

LPS+ PGE3 (5 mg/kg + 1 µmol/L)
Administration:

I.p.; once
Result:

Significantly reduced MPMs with an M1-like phenotype and increased M2-like MPMs, inhibited inflammatory cytokine secretion in both the serum and MPM cell lysates.

Chemical Information

CAS No. 802-31-3
Appearance Liquid
분자량 350.45
화학식 C₂₀H₃₀O₅
Color Colorless to light yellow
SMILES

CC/C=C\C[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)C/C=C\CCCC(O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Solution, -20°C, 2 years

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cui J, et al. Prostaglandin E3 attenuates macrophage-associated inflammation and prostate tumour growth by modulating polarization. J Cell Mol Med. 2021 Jun;25(12):5586-5601. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
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수량:
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상품명:
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수량:

Prostaglandin E3

Dexamethasone acetate

Pranoprofen

Latanoprost

Tafluprost acid

Bimatoprost acid

Dexamethasone acetate (Standard)

VAF347

Bimatoprost grenod

Prostaglandin F2α ethanolamide

Prostaglandin F2α methyl ester

PGF2α-isopropyl ester

Bimatoprost methyl ester

All Prostaglandin Receptor Isoforms

All PKA Isoforms

All COX Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

Prostaglandin E3

Dexamethasone acetate

Pranoprofen

Latanoprost

Tafluprost acid

Bimatoprost acid

Dexamethasone acetate (Standard)

VAF347

Bimatoprost grenod

Prostaglandin F2α ethanolamide

Prostaglandin F2α methyl ester

PGF2α-isopropyl ester

Bimatoprost methyl ester

All Prostaglandin Receptor Isoforms

All PKA Isoforms

All COX Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Prostaglandin E3 Related Classifications

HY-113481 Related Classifications

Bioz