Trk
The Trk (tropomyosin receptor kinase) family comprises three receptor tyrosine kinases, NTRK1 (TRKA), NTRK2 (TRKB) and NTRK3 (TRKC), so named for their initial co-purification with tropomyosin. Each contains extracellular immunoglobulin-like and leucine-rich repeat domains and binds a distinct neurotrophin: nerve growth factor activates TRKA, brain-derived neurotrophic factor and NT4/5 activate TRKB, and neurotrophin-3 preferentially activates TRKC. Trk signaling through Ras-MAPK, PI3K-AKT and PLCγ pathways governs neuronal survival, differentiation, synaptic plasticity and pain sensation. Chromosomal NTRK fusions, first recognized in colorectal and papillary thyroid carcinomas, occur at low frequency across many cancers and define a pan-tumor indication for the highly effective inhibitors larotrectinib and entrectinib.
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Trk Recombinant Proteins (8)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
