Remigromig
Based on 1 Customer Validation
Remigromig (EYE-103; MK-3000) is a humanized dual-target monoclonal antibody that targets LRP5 and FZD4. Remigromig activates the Wnt/β-catenin signaling pathway by mimicking the natural ligand Norrin, induces tight junction formation and restores blood-retinal barrier function. Administered via intravitreal injection, Remigromig reduces retinal vascular leakage, and demonstrates improvements in best-corrected visual acuity and reductions in retinal thickness in studies of diabetic macular edema. Remigromig can be used for research related to macular degeneration.
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- Purity: 95.25%
- CAS No.: 3059389-31-7
- 분자량:199.68 kDa
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
제품 설명
Isotype
immunoglobulin [(diabody VH1-Vk2-G1(h-CH2-CH3)-VH-G1(CH1-h)_Lkappa)]_[( diabody VH2-Vk1-G1(h-CH2-CH3)-VH-G1(CH1-h)_L-kappa)]
Species Reactivity
Human
In Vitro
Remigromig activates the Wnt/β-catenin signaling pathway by mimicking the natural ligand Norrin, induces tight junction formation in endothelial cells, and enhances the function of the blood-retinal barrier[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
Accession
O75197 & Q9ULV1
Target
LRP5 & FZD4
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
신청
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Frizzled-4/CD344 Protein, Human (HEK293, HY-P74140) can bind Remigromig. The ED50 for this effect is 17.22 ng/mL. -
Immobilized LRP-5 Protein, Human (HEK293, HY-P77989) can bind Remigromig. The ED50 for this effect is 891.6 ng/mL.
Chemical Information
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CAS No. 3059389-31-7
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Appearance Liquid
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분자량 199.68 kDa
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Color Colorless to light yellow
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SMILES
[Remigromig]
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Synonyms
EYE-103; MK-3000
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- Remigromig
- 3059389-31-7
- EYE-103
- MK-3000
- EYE103
- EYE 103
- MK3000
- MK 3000
- MK-3000
- Wnt
- Wnt/β-catenin signaling
- Dutch Belted rabbits
- tight junction proteins
- blood-retina barrier
- oxygen-induced retinopathy mice
- diabetic retinopathy
- FZD4
- bEnd.3 mouse brain microvascular endothelial cells
- LRP5
- blood-brain barrier
- Inhibitor
- inhibitor
- inhibit