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Cat. No.: HY-14334

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SAM-315

Name: SAM-315
Brand: MedChemExpress
SKU: HY-14334
Availability: PreOrder

(Synonyms: WAY-255315)

SAM-315 (WAY-255315) is a potent antagonist of 5-Hydroxytryptamine-6, with K_i and IC₅₀ of 1.1 nM and 4.6 nM, respectively. SAM-315 significantly increases acetylcholine and glutamate release in hippocampus of the brain.

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CAS No.: 744218-85-7
화학식: C₂₁H₂₀N₄O₂S
분자량:392.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SAM-315 Chemical Structure

CAS No.: 744218-85-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- Clinical Trial
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

5-HT₆ Receptor

4.6 nM (IC₅₀)

All 5-HT Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	13 nM Compound: 8at	Antagonist activity at human cloned 5HT6 receptor expressed in human HeLa cells by cyclase assay Antagonist activity at human cloned 5HT6 receptor expressed in human HeLa cells by cyclase assay	[PMID: 20932009]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 744218-85-7
분자량 392.47
화학식 C₂₁H₂₀N₄O₂S
SMILES

O=S(C1=NNC2=C1C=C(N3CCNCC3)C=C2)(C4=CC=CC5=C4C=CC=C5)=O
Synonyms

WAY-255315
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. 5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists J. Med. Chem., Article ASAP DOI: 10.1021/jm1007825 Publication Date (Web): October 8, 2010

[2]. Kevin G Liu, et al. 5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists. J Med Chem. 2010 Nov 11;53(21):7639-46. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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