SB-209247
Based on 1 publication(s) in Google Scholar
SB-209247 is a selective, high affinity and orally active leukotriene B4 (LTB4) receptor antagonist with a Ki of 0.78 nM. SB-209247 blocks LTB4-induced Ca2+ mobilization with an IC50 of 6.6 nM. SB-209247 shows a potent anti-inflammatory activity.
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- Purity : 99.33%
- CAS No.: 154413-61-3
- 화학식: C23H19Cl2NO3S
- 분자량:460.37
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) SB-209247
MoreAll Leukotriene Receptor Isoforms
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Biological Activity
제품 설명
IC50 & Target
[1]|
LTB4 0.78 nM (Ki) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| RBL-1 | IC50 |
8200 nM
Compound: 3
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Concentration required to inhibit RBL-1 supernatant 5-lipoxygenase
Concentration required to inhibit RBL-1 supernatant 5-lipoxygenase
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[PMID: 8809171] |
In Vitro
SB-209247 (Compound 3) demonstrates a high degree of selectivity for the LTB4 receptor. SB-209247 competes with [3H]-fMLP and [3H]LTD4 in respective receptor binding assays with IC50 values of 3250 nM and 16800 nM and with another 14 ligands with IC50 values greater than 10000 nM. Functional activity at the cellular level is demonstrated in human polymorphonuclear leukocytes (PMNs) by blocking the LTB4-induced Ca2+ mobilization and LTB4-induced degranulation with IC50 values of 6.6 nM and 53 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 154413-61-3
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Appearance Solid
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분자량 460.37
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화학식 C23H19Cl2NO3S
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Color White to off-white
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SMILES
O=C(O)/C=C/C1=NC(CSC2=C(Cl)C=CC=C2Cl)=CC=C1OCCC3=CC=CC=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Leukoc Biol
Caging giants: Characterizing the molecular mechanisms of neutrophil swarming against Candida albicans hyphae. [Abstract]2025 Jul 9;117(7):qiaf082. PMID: 40476443
순도&문서
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SB-209247 Related Classifications
HY-112741 Related Classifications
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