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Cat. No.: HY-150895

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SI-191

SI-191 is a STAT3 inhibitor and a target protein ligand. SI-191 inhibits the growth of cancer cells. SI-191 can be used in the research of acute leukemia and lymphoma. SI-191 can be used for the synthesis of PROTAC SD-91 (HY-150251).

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CAS No.: 2754428-37-8
화학식: C₄₀H₄₄N₇O₁₀P
분자량:813.79

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SI-191 Chemical Structure

CAS No.: 2754428-37-8

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

STAT3

All STAT Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
SU-DHL-1	IC₅₀	>10 μM Compound: SI-191	Antiproliferative activity against human SU-DHL-1 cells assessed as cell growth inhibition incubated for 4 days by CellTiter-Glo asssay Antiproliferative activity against human SU-DHL-1 cells assessed as cell growth inhibition incubated for 4 days by CellTiter-Glo asssay	[PMID: 34141084]

In Vitro

SI-191 (>10 μM) inhibits the growth of MOLM-16 acute leukemia cells, SU-DHL-1 lymphoma cells, and SUP-M2 lymphoma cells with IC₅₀ values greater than 10 μM for all three cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2754428-37-8
분자량 813.79
화학식 C₄₀H₄₄N₇O₁₀P
SMILES

CC(N1CC[C@H]2CC[C@H](N2C([C@H](C1)NC(C3=CC4=CC(C(P(O)(O)=O)=O)=CC=C4N3)=O)=O)C(N[C@H](C(NC(C5=CC=CC=C5)C6=CC=CC=C6)=O)CCC(N)=O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Zhou H, et al. SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression. ACS Med Chem Lett. 2021 May 10;12(6):996-1004. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
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SI-191

All STAT Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SI-191 Related Classifications

HY-150895 Related Classifications