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Cat. No.: HY-150254

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SLB1122168

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

SLB1122168 is a Spinster Homolog 2 (Spns2) inhibitor. SLB1122168 inhibits Spns2-mediated sphingosine-1-phosphate (S1P) release with an IC₅₀ of 94 nM. SLB1122168 induces lymphopenia in circulating lymphocytes in mice and rats.

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CAS No.: 2999629-17-1
화학식: C₂₂H₃₆ClN₃O
분자량:393.99

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

SLB1122168 Chemical Structure

CAS No.: 2999629-17-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

S1P

All LPL Receptor Isoforms :

In Vitro

SLB1122168 (Compound 33p) (0.3 μM; 18-20 h) potently inhibits Spns2-mediated S1P release in mouse Spns2-transfected HeLa cells with an IC₅₀ of 94 nM^[1].
SLB1122168 (10 μM) shows no inhibitory activity against Mfsd2b-mediated S1P release from mouse red blood cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SLB1122168 (Compound 33p) (10-30 mg/kg; i.p.; single dose) induces a significant, dose-dependent decrease in circulating lymphocytes without altering plasma S1P levels in female C57BL/6J mice^[1].
SLB1122168 (10 mg/kg; i.p.; single dose) induces a 55% decrease in circulating lymphocytes in male Sprague-Dawley rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (female)^[1]
Dosage:

10 mg/kg; 30 mg/kg
Administration:

i.p.; single dose
Result:

Induced a significant decrease in circulating lymphocytes relative to vehicle control at 4 h post-dose.
Caused no significant change in plasma S1P levels at 4 h post-dose.
Induced a dose-dependent decrease in circulating lymphocytes relative to vehicle control at 16 h post-dose.

Chemical Information

CAS No. 2999629-17-1
분자량 393.99
화학식 C₂₂H₃₆ClN₃O
SMILES

CCCCCCCCCCC1=CC=C2C(OC(NC[C@@H]3CNCC3)=N2)=C1.Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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PLoS Pathog

A Spinster-like Transporter at the Inner Membrane Complex is critical for Toxoplasma gondii cytokinesis, motility and invasion. [Abstract]

2026 Jan 28;22(1):e1013886. PMID: 41604433

순도&문서

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ariel L Burgio, et al. 2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2). J Med Chem. 2023 Apr 27;66(8):5873-5891. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

SLB1122168

1 Cited Publications

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Biological Activity
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- In Vitro
- In Vivo
Chemical Information
Publications (1)
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SLB1122168

Publications Citing Use of MedChemExpress (MCE) SLB1122168

All LPL Receptor Isoforms

Biological Activity

Chemical Information

Publications (1)

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SLB1122168 Related Classifications

HY-150254 Related Classifications