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Cat. No.: HY-155294

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SM-122

SM-122 is a monovalent Smac mimetic targeting cellular inhibitor of apoptosis protein (cIAP)-1/2. SM-122 can induce cIAP-1/2 degradation and weakly induce apoptosis in tumor cells. SM-122 can be used for the research of cancer, such as breast cancer.

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CAS No.: 874270-38-9
화학식: C₂₈H₃₆N₄O₃
분자량:476.61

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

SM-122 Chemical Structure

CAS No.: 874270-38-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

cIAP-1

cIAP-2

All IAP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	1400 nM Compound: 18; SM-122	Cytotoxicity against human HL60 cells assessed as reduction in cell viability Cytotoxicity against human HL60 cells assessed as reduction in cell viability	[PMID: 30676015]
MDA-MB-231	EC₅₀	1.03 μM Compound: 1, SM-122	Reversal of human XIAP BIR3-mediated suppression of cytochrome c-induced caspase-3/-7 activity in human MDA-MB-231 cell lysate after 30 mins by cell free functional assay Reversal of human XIAP BIR3-mediated suppression of cytochrome c-induced caspase-3/-7 activity in human MDA-MB-231 cell lysate after 30 mins by cell free functional assay	[PMID: 19049347]
MDA-MB-231	IC₅₀	259 nM Compound: 1, SM-122	Growth inhibition of human MDA-MB-231 cells after 4 days by WST8 assay Growth inhibition of human MDA-MB-231 cells after 4 days by WST8 assay	[PMID: 19049347]
MDA-MB-231	IC₅₀	259 nM Compound: 7, SM-122	Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay	[PMID: 19138149]
MDA-MB-231	IC₅₀	410 nM Compound: 20	Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay	[PMID: 18954041]
MDA-MB-231	IC₅₀	633 nM Compound: 15, SM-125	Growth inhibition of human MDA-MB-231 cells after 2 to 3 hrs by WST8 assay Growth inhibition of human MDA-MB-231 cells after 2 to 3 hrs by WST8 assay	[PMID: 21462933]
SK-OV-3	IC₅₀	900 nM Compound: 20	Growth inhibition of human SKOV3 cells after 4 days by WST8 assay Growth inhibition of human SKOV3 cells after 4 days by WST8 assay	[PMID: 18954041]

Chemical Information

CAS No. 874270-38-9
분자량 476.61
화학식 C₂₈H₃₆N₄O₃
SMILES

O=C([C@H]1N2[C@](CCCC[C@@H](C2=O)NC([C@H](C)NC)=O)([H])CC1)NC(C3=CC=CC=C3)C4=CC=CC=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lu J, et al. SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Res. 2008 Nov 15;68(22):9384-93. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

SM-122

All IAP Isoforms