SMS2-IN-3
SMS2-IN-3 is a potent and selective SMS2inhibitor (IC50=2.2 nM), significantly reduces the hepatic SM (22:0) levels.
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- CAS No.: 2414240-89-2
- 화학식: C33H39F3N4O6
- 분자량:644.68
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
IC50: 2.2nM (SMS2)[1]
SMS2-IN-3 (37) is an excellent sphingomyelin synthase 2 inhibitor (SMS2). SMS2-IN-3 (37) has inhibition (IC50= 2.2 nM) and good selectivity against SMS1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:FreeStyle293 cells
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Concentration:100mg/kg
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Incubation Time:60 min
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Result:Showed excellent SMS2 inhibition and good selectivity against SMS1 in biological evaluation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:KK-Ay/Ta mice[1]
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Dosage:100, 200 mg/kg
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Administration:SMS2-IN-3: s.c. (100, 200 mg/kg); p.o. (100, 200 mg/kg); once or twice per day for 7 days.
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Result:
cmpd Cmax, (μg/mL) Tmax, (h) C24 h, (μg/mL) AUC0-24(μg•h/mL) MRT(h) 37(p.o.) 6.5 0.83 0.007 18 3.0 37(s.c.) 0.70 8.0 0.23 12 9.4
Chemical Information
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CAS No. 2414240-89-2
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분자량 644.68
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화학식 C33H39F3N4O6
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SMILES
O=C(N1CCC(CCCOC(C2=C(N3C)N=CC=C2)=C(C(N(CC4=CC(OC)=CC(C(F)(F)F)=C4)C)=O)C3=O)CC1)OC5(CC5)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SMS2-IN-3 Related Classifications
HY-150559 Related Classifications
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