SR-3-65
SR-3-65 (compound 6) is a Indisulam (HY-13650) derivative,and inhibits the migration of gastric cancer cells. SR-3-65 attenuates PI3K/AKT/GSK-3β/β-catenin signaling pathway.
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- 화학식: C16H9ClF3N3O2S
- 분자량:399.77
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
SR-3-65 (0.0001-100 µM, 48h) inhibits the cell growth of AGS cells with the IC50 of 24.75 μM[1].
SR-3-65 (10 µM, 48-72 h) shows anti-migration activity in AGS and MGC803 cells[1].
SR-3-65 (10 µM, 48 h) upregulates E-cadherin and downregulated N-cadherin and vimentin in AGS and MGC803 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:AGS cells
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Concentration:0.0001-100 µM
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Incubation Time:48 h
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Result:Inhibited the cell growth of AGS cells with the IC50 of 24.75 μM。
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Cell Line:AGS and MGC803 cells
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Concentration:10 µM
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Incubation Time:48-72 h
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Result:Showed anti-migration activity in AGS and MGC803 cells.
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Cell Line:MGC803 cells
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Concentration:10 µM
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Incubation Time:48 h
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Result:Upregulated E-cadherin and downregulated N-cadherin and vimentin.
Chemical Information
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분자량 399.77
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화학식 C16H9ClF3N3O2S
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SMILES
O=S(C1=CC=CC(C#N)=C1)(NC2=CC(C(F)(F)F)=CC3=C2NC=C3Cl)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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