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Cat. No.: HY-183450

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Supradamal

Supradamal is a peptidyl-prolyl cis-trans isomerase (PPIase) inhibitor with an IC₅₀ of 83 nM against *Plasmodium falciparum* and an IC₅₀ of 75 nM against *Plasmodium vivax*. Supradamal inhibits the development, maturation and in vitro growth of *Plasmodium falciparum* trophozoites. Supradamal is applicable to malaria-related research.

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CAS No.: 71458-51-0
화학식: C₁₇H₂₁N₃O₂
분자량:299.37

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Supradamal Chemical Structure

CAS No.: 71458-51-0

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Parasite Isoforms :

In Vitro

Supradamal inhibits the growth of Plasmodium falciparum in human red blood cells, including the development of trophozoites^[1].
Supradamal (Compound 4a) inhibits the peptidyl-prolyl isomerase activity of purified Plasmodium falciparum FKBD35, with an IC₅₀ of 83 nM^[3].
Supradamal inhibits the peptidyl-prolyl isomerase activity of purified Plasmodium vivax FKBD35 with an IC₅₀ of 75 nM^[3].
Supradamal (48 h) inhibits the growth of *Plasmodium falciparum* strain 3D7 in vitro by specifically interfering with the development of the trophozoite stage, while exerting no effect on ring-stage parasites^[3].
Supradamal (500 nM; 4-16 h) specifically inhibits the development of trophozoite-stage parasites of the Plasmodium falciparum 3D7 strain, with no effect on ring-stage or schizont-stage parasites^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 71458-51-0
Appearance Solid
분자량 299.37
화학식 C₁₇H₂₁N₃O₂
SMILES

O=C(C1=CC=NC=C1)NNC(C23CC4CC(C3)CC(C2)C4)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Yoon, H.S., et al. Mechanistic insights into non-immunosuppressive immunophilin ligands as potential antimalarial therapeutics. Malar J 9 (Suppl 2), P60 (2010).

[2]. Rasch J, et al. Novel Cycloheximide Derivatives Targeting the Moonlighting Protein Mip Exhibit Specific Antimicrobial Activity Against Legionella pneumophila. Frontiers in bioengineering and biotechnology. 2015;3:41. [Content Brief]

[3]. Harikishore A, et al. Adamantyl derivative as a potent inhibitor of Plasmodium FK506 binding protein 35. ACS medicinal chemistry letters. 2013 Nov 14;4(11):1097-101. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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수량:
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Supradamal

All Parasite Isoforms