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Cat. No.: HY-180424

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SYAF080

SYAF080 is a human A₂B adenosine receptor (hA₂B AdoR) antagonist with a K_i of 23.6 nM and a K_B of 25.2 nM. SYAF080no relevant inhibition of human CYP450 cytochromes. SYAF080 can be used for the research of inflammation, metabolic and cardiovascular disease.

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CAS No.: 352692-70-7
화학식: C₁₂H₁₄N₂O₃S
분자량:266.32

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SYAF080 Chemical Structure

CAS No.: 352692-70-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

hA_2B

23.6 nM (Ki)

hA_2B

25.2 nM (Kb)

All Adenosine Receptor Isoforms :

In Vitro

SYAF080 (Compound 21a) (10 µM) inhibits hA1, hA2A, hA2B and hA3 (Ki = 23.6 nM for hA2B; KB = 25.2 nM) and inhibits c-AMP production^[1].
SYAF080 shows no relevant inhibition of human CYP450 cytochrome^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 352692-70-7
분자량 266.32
화학식 C₁₂H₁₄N₂O₃S
SMILES

O=C(OCC)C1=C(NC(=O)NC1C2=CSC=C2)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Crespo A, et al. Discovery of 3,4-Dihydropyrimidin-2(1H)-ones As a Novel Class of Potent and Selective A2B Adenosine Receptor Antagonists. ACS Med Chem Lett. 2013;4(11):1031-1036. Published 2013 Oct 3. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
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수량:
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SYAF080

All Adenosine Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SYAF080 Related Classifications

HY-180424 Related Classifications