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Cat. No.: HY-204388

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TAK-137

TAK-137 is an AMPA receptor potentiator with weak agonistic effect. TAK-137 binds to the AMPA receptor ligand binding domain in a glutamate-dependent manner. TAK-137 potentiates AMPA-induced currents and Ca²⁺ influx. TAK-137 can be used for the research of neurological disease.

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CAS No.: 1358749-55-9
화학식: C₁₉H₁₆N₂O₃S
분자량:352.41

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

TAK-137 Chemical Structure

CAS No.: 1358749-55-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
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Biological Activity

제품 설명

IC₅₀ & Target^[1]

AMPA Receptor

All iGluR Isoforms :

All Calcium Channel Isoforms :

In Vitro

TAK-137 (30 μM; 60 min) potentiates AMPA-induced Ca²⁺ influx in rat primary hippocampal neurons with an EC₅₀ of 0.42 μM and exhibits a 7.6% agonistic effect at 30 μM in the absence of AMPA^[1].
TAK-137 (30 μM) potentiates AMPA-induced currents in rat primary hippocampal neurons with an EC₅₀ of 1.4 μM and exhibits a 6.4% agonistic effect at 30 μM in the absence of AMPA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1358749-55-9
분자량 352.41
화학식 C₁₉H₁₆N₂O₃S
SMILES

O=S1(=O)N=C2C(=CC=CN2CC1)C=3C=CC(OC=4C=CC=CC4)=CC3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Suzuki A, et al. Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement[J]. Scientific Reports, 2021, 11(1): 14532. [Content Brief]

Calculators

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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TAK-137

All iGluR Isoforms

All Calcium Channel Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

TAK-137 Related Classifications

HY-204388 Related Classifications