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Cat. No.: HY-119407

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Terpendole E

Terpendole E is a mitotic kinesin Eg5 inhibitor. Terpendole E inhibits both motor and microtubule-stimulated ATPase activities of human Eg5. Terpendole E induces formation of a monoastral spindle in M phase.

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CAS No.: 167427-23-8
화학식: C₂₈H₃₉NO₃
분자량:437.61

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Terpendole E Chemical Structure

CAS No.: 167427-23-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

Eg5

All Kinesin Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	31.1 μM Compound: 9	Cytotoxicity against human A2780 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A2780 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26356746]
A549	IC₅₀	18.82 μM Compound: 9	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26356746]
HeLa	IC₅₀	12.1 μM Compound: 10	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by SF-based cell counting method Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by SF-based cell counting method	[PMID: 27865702]
K562	IC₅₀	38.7 μM Compound: 9	Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26356746]
MDA-MB-231	IC₅₀	39.22 μM Compound: 9	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26356746]

Chemical Information

CAS No. 167427-23-8
분자량 437.61
화학식 C₂₈H₃₉NO₃
SMILES

C[C@]12C3=C(C4=CC=CC=C4N3)C[C@]1([H])CC[C@]5([H])[C@@]2(CC[C@@]6([H])[C@]5([C@@H](C[C@H](O6)C(C)(O)C)O)C)C
Structure Classification
- Terpenoids
- Iridoids
Initial Source
- Microorganisms
soil-isolated fungus
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Junko Nakazawa, et al. A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5. Chem Biol. 2003 Feb;10(2):131-7. [Content Brief]

Calculators

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Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
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Terpendole E

All Kinesin Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Terpendole E Related Classifications

HY-119407 Related Classifications